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Biopsies from patients included in 2 previous published studies, I involving patients from the United States (eastern Massachusetts) and I from Denmark, were evaluated for EBV RNA (EBER\u20101) and latent membrane protein (LMP\u2010I). The presence of EBV in Reed\u2010Sternberg cells in the biopsies correlated with the histologic subtype of HD (mixed cellularity and lymphocyte depletion) but not with IgG antibody titers against the viral capsid antigen (VCA). These data suggest that, unlike Burkitt's lymphoma, the IgG antibody against VCA is not predictive of the presence or absence of EBV in Reed\u2010Sternberg cells in HD. The predictive value of other antibodies should be evaluated.<\/jats:p>","DOI":"10.1002\/ijc.2910590111","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:19:30Z","timestamp":1171930770000},"page":"48-50","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of epstein\u2010barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease"],"prefix":"10.1002","volume":"59","author":[{"given":"Paul H.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorm","family":"Pallesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ebbesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred S.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"M\u00fceller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.2.462.462"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940030105"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)92675-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080203"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/oxfordjournals.epirev.a036213","article-title":"The epidemiology of Burkitt's lymphoma: evidence for a causal association with Epstein\u2010Barr virus","volume":"1","author":"de Th\u00e9 G.","year":"1979","journal-title":"Epidemiol. 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