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In order to find whether PSC might display specific myelotoxicity or potentiate the toxicity of anti\u2010cancer drugs, healthy mice were exposed to single doxorubicin (DOX) and combined (DOX + PSC) chemotherapy protocols known to be near or above the borderline of toxicity for tumor\u2010bearing mice. Mice treated with DOX alone or with (DOX + PSC) showed transient spleen hypoplasia, with a general decrease of all leucocyte lineages and a persistent fall in the numbers of B cells in the bone marrow. In (DOX + PSC)\u2010treated mice, PSC only potentiated the DOX effects without inducing specific depletions of the Pgp\u2010expressing leukocytes (CD8<jats:sup>+<\/jats:sup> and Mac\u2010l<jats:sup>+<\/jats:sup> cells). Hematopoietic cell grafts from normal mice to (DOX \u00b1 PSC)\u2010treated mice did not correct their B\u2010cell lineage deficiency. When lethally irradiated mice were rehabilitated with hematopoietic cells from (DOX \u00b1 PSC)\u2010treated mice (including those with very reduced survival), all chimeras survived for at least 8 months after the cell graft, at which time their leucocyte population profiles were similar to those of control chimeras.<\/jats:p>","DOI":"10.1002\/ijc.2910590123","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:19:30Z","timestamp":1171930770000},"page":"133-140","source":"Crossref","is-referenced-by-count":9,"title":["Myeloid and lymphoid cell alterations in normal mice exposed to chemotherapy with doxorubicin and\/or the multidrug\u2010resistance reversing agent SDZ PSC 833"],"prefix":"10.1002","volume":"59","author":[{"given":"Sylvie","family":"Froidevaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Loor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.15.1234"},{"key":"e_1_2_1_3_1","first-page":"4226","article-title":"In vivo circumvention of P\u2010glycoprotein\u2010mediated multidrug resistance of tumor cells with SDZ PSC 833","volume":"51","author":"Boesch D.","year":"1991","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90141-K"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00427.x"},{"key":"e_1_2_1_6_1","first-page":"225","article-title":"SDZ PSC 833, a non\u2010immunosuppressive cyclosporin analog, is a very potent multidrug\u2010resistance modifier","volume":"2","author":"Gav\u00e9riaux C.","year":"1991","journal-title":"J. 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