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Its pattern of expression appears to differ from that described for other drug\u2010resistance\u2010 and\/or tumor\u2010associated antigens. In normal tissues, the antigen has a restricted histological distribution and appears to be localized in mesoderm\u2010derived tissues. In tumor tissues, VRA09 expression was mainly detected in serous ovarian tumors. Indeed, VRA09 is strongly expressed in papillary serous cystadenocarcinomas and their metastases, and more specifically in the basement membranes of serous tumors of borderline malignancy. In contrast, no immunostaining was observed in normal ovarian tissue or benign tumors. The detection of this antigen may help to identify serous ovarian tumors by distinguishing tumors of low malignancy from cystadenocarcinomas.<\/jats:p>","DOI":"10.1002\/ijc.2910590203","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:17:20Z","timestamp":1171930640000},"page":"159-164","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of VRA09, an ovarian tumor\u2010associated antigen, distinguishing borderline serous tumors"],"prefix":"10.1002","volume":"59","author":[{"given":"Thibault","family":"Voeltzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duvillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Ghillani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"B\u00e9nard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Bohuon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bellet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Bidart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90288-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(87)80040-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110380"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90201-F"},{"key":"e_1_2_1_6_1","first-page":"4970","article-title":"Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice","volume":"45","author":"B\u00e9nard J.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910430322"},{"key":"e_1_2_1_8_1","first-page":"270","article-title":"The immunobiology and immunotherapy of ovarian cancer","volume":"18","author":"Bookman M. 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