{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:14:21Z","timestamp":1791101661938,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mortality has been studied in 15,577 ankylosing spondylitis (AS) patients diagnosed between 1935 and 1957 in the UK, of whom 14,556 received X\u2010ray treatment. By January 1, 1992 over half of the cohort had died. Among the irradiated patients, cancer mortality was significantly greater than expected from the national rates for England and Wales, with a ratio of observed deaths to expected (relative risk, RR) of 1.30, and significant increases individually for leukaemia, non\u2010Hodgkin's lymphoma, multiple myeloma and cancers of the oesophagus, colon, pancreas, lung, bones, connective and soft tissue, prostate, bladder and kidney. Among the unirradiated patients, cancer mortality was lower than expected from national rates (RR = 0.79). Among irradiated patients, the RRs for leukaemia, lung cancer, and all other neoplasms all decreased significantly with increasing time since first treatment following an initial increase. By 35 years after first treatment, the radiation\u2010related excess for lung cancer had completely disappeared, while for other neoplasms the RR remained significantly raised, although at a lower level than in earlier periods. Most irradiated patients received several courses of treatment within a 5\u2010year period. Based on a 1 in 15 random sample, the mean total body dose received in this period was 2.64 Gy, with the heaviest dose to the vertebrae. A linear dose\u2010response model for all neoplasms except leukaemia gave an excess RR of 0.18 Gy<jats:sup>\u22121<\/jats:sup> in the period 5\u201324.9 years after first treatment, which decreased significantly to 0.11 Gy<jats:sup>\u22121<\/jats:sup> in the period more than 25 years after first treatment. There was no evidence that a linear\u2010quadratic model fitted the data better than a linear model. There were significant dose\u2010response relationships individually for cancers of the lung, oesophagus, colon, pancreas, prostate, bladder and kidney. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910590307","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:16:36Z","timestamp":1171930596000},"page":"327-338","source":"Crossref","is-referenced-by-count":167,"title":["Cancer mortality following X\u2010ray treatment for ankylosing spondylitis"],"prefix":"10.1002","volume":"59","author":[{"given":"Helen A.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Darby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Doll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(56)91481-7"},{"key":"e_1_2_1_3_1","first-page":"955","article-title":"Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries","volume":"74","author":"Boice J. D.","year":"1985","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/3577477"},{"key":"e_1_2_1_5_1","first-page":"801","article-title":"A prospective nationwide cross\u2010sectional study of NSAID usage in 1,331 patients with ankylosing spondylitis","volume":"17","author":"Calin A.","year":"1990","journal-title":"J. Rheumatol."},{"key":"e_1_2_1_6_1","volume-title":"Leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis","author":"Court\u2010Brown W. 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