{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:09:56Z","timestamp":1789596596722,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with breast cysts lined by apocrine epithelium (intracystic Na\/K &lt;3) may have a higher risk of developing breast cancer than those whose breast cysts are lined by \u201cflattened\u201d epithelium (intracystic Na\/K &lt;3). In this study, the concentrations of the cytokines, oncostatin M (OSM), interleukin 2 (IL\u20102), interleukin 6 (IL\u20106) and interleukin 8 (IL\u20108) were measured in breast cyst fluid, OSM, IL\u20102 and IL\u20106 having been shown to have growth\u2010inhibitory actions on tumour cells. All cytokines were measured by \u201csandwich\u201d enzyme immunoassays. IL\u20102 was not detectable in breast cyst fluid. OSM, IL\u20106 and IL\u20108 concentrations were significantly higher in the high\u2010electrolyte\u2010ratio group. Although significant positive correlations were found between OSM and IL\u20106, OSM and IL\u20108, OSM and Na\/K, IL\u20106 and IL\u20108, IL\u20106 and Na\/K and IL\u20108 and Na\/K when all samples were analysed together, analysis of the correlations between these analytes in each subgroup separately suggests that the control of production of these cytokines or the mechanism of entry into cyst fluid is likely to be different for the 2 cyst types. The significantly higher intracystic concentrations of OSM and IL\u20106 in the high\u2010electrolyte\u2010ratio group may partly explain the lower risk of breast cancer in this group of women. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910590313","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:16:36Z","timestamp":1171930596000},"page":"369-372","source":"Crossref","is-referenced-by-count":12,"title":["Oncostatin M, interleukin 2, interleukin 6 and interleukin 8 in breast cyst fluid"],"prefix":"10.1002","volume":"59","author":[{"given":"Leslie C.","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Kadory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul K.","family":"Siraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W. 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