{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:20:45Z","timestamp":1784755245284,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATL) is a malignancy that occurs most frequently in south\u2010western Japan and the Caribbean basin. The primary etiologic agent for this disease, human T\u2010lymphotropic virus type I (HTLV\u2010I), is endemic in these areas. Only a small percentage of individuals infected with HTLV\u2010I develop ATL. The factors that determine the development of malignant disease as an outcome of HTLV\u2010I infection in an individual are unknown. ATL is histopathologically heterogeneous and firm diagnosis is made on the contribution of clinical, laboratory and histopathologic features. The wide variety of laboratory assays available to geographically diverse populations has led to a need to standardize the criteria for determining the diagnosis of this disease for epidemiologic studies. This report summarizes current information regarding ATL and proposes a classification facilitating comparison of case series in geographically and ethnically different populations. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910590410","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:16:31Z","timestamp":1171930591000},"page":"491-493","source":"Crossref","is-referenced-by-count":39,"title":["Adult T\u2010Cell leukemia\/lymphoma: A working point\u2010score classification for epidemiological studies"],"prefix":"10.1002","volume":"59","author":[{"given":"Paul H.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farley","family":"Cleghorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Navarro\u2010Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barrie","family":"Hanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"De Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunro","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takatsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92200-0"},{"key":"e_1_2_1_4_1","first-page":"185","volume-title":"Human retrovirology: HTLV","author":"Cleghorn F. R.","year":"1990"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530110"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92432-H"},{"key":"e_1_2_1_7_1","first-page":"84","article-title":"Lymphomes T leuc\u00e9miques de I'adulte avec s\u00e9rologie HTLV\u2010I positive. A propos d'un cas","volume":"27","author":"Dombret H.","year":"1985","journal-title":"Nouv. Rev. Fr. H\u00e9matol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.25100\/cm.v16i.1.3456","article-title":"Neoplasias linfoides asociadas con anticuerpos contra el virus humano de linfomas\u2010leucemias de c\u00e9lulas T en Colombia","volume":"16","author":"Duque E. E.","year":"1985","journal-title":"Colombia Med."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91431-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-3-361"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340505"},{"key":"e_1_2_1_12_1","first-page":"173","volume-title":"Human retrovirology: HTLV","author":"Hanchard B.","year":"1993"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198404000-00003"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<851::AID-CNCR2820550424>3.0.CO;2-J"},{"key":"e_1_2_1_16_1","first-page":"37","article-title":"Biopsy of adult T\u2010cell leukemia","volume":"28","author":"Kikuchi M.","year":"1982","journal-title":"GANN"},{"key":"e_1_2_1_17_1","first-page":"215","article-title":"Human T\u2010cell lymphotropic virus type I and adult T\u2010cell leukemia\/lymphoma outside Japan and the Caribbean Basin","volume":"61","author":"Levine P. H.","year":"1988","journal-title":"Yale J. Biol. Med."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560205"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890601)63:11<2186::AID-CNCR2820631121>3.0.CO;2-J"},{"key":"e_1_2_1_20_1","first-page":"891","article-title":"Human T\u2010cell\u2010leukemia\/lymphoma\u2010virus(HTLV\u2010I) DNA: detection in Italy in a lymphoma and in a Kaposi's\u2010sarcoma patient","volume":"34","author":"Manzari V.","year":"1984","journal-title":"Int. J. Cancer"},{"key":"e_1_2_1_21_1","volume-title":"Adult T\u2010cell leukemia","author":"Matutes E.","year":"1994"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198811000-00004"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6760397"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4524"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3<590::AID-CNCR2820650334>3.0.CO;2-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91202-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880515)61:10<2060::AID-CNCR2820611022>3.0.CO;2-D"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450206"},{"key":"e_1_2_1_31_1","series-title":"Excerpta Medica Int. Congr. Series","first-page":"73","volume-title":"Topics in hematology","author":"Takatsuki K.","year":"1977"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6429.1495"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910590410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910590410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T22:19:46Z","timestamp":1736806786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910590410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,15]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,11,15]]}},"alternative-id":["10.1002\/ijc.2910590410"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910590410","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11,15]]}}}