{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:36:24Z","timestamp":1784194584980,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt's lymphoma (BL) is a very high\u2010incidence malignancy in sub\u2010Saharan Africa, where it targets mainly young children. This lymphoma is closely associated with Epstein\u2010Barr virus (EBV). Diagnosis of BL relies on clinical presentation as well as histological results obtained from biopsies. In this report, 66 new patients from Malawi (one of the southernmost African countries with high\u2010incidence BL), suspected on clinical grounds to present with BL, had fine needle aspiration biopsies taken, smeared on slides and used for May\u2010Gr\u00fcnwald Giemsa staining. Duplicate slides were independently assessed for EBV presence and expression by DNA\u2010DNA and\/or RNA\u2010RNA <jats:italic>in situ<\/jats:italic> hybridisation (ISH), using respectively the repetitive viral <jats:italic>Bam<\/jats:italic>HIW DNA fragment in a biotinylated probe and the small EBV\u2010encoded RNA EBER I in a digoxigenin\u2010labelled riboprobe. There was very good correlation between the various techniques in the diagnosis of the lymphomas, showing 67% of clinically suspect cases to be BL. Our report, presenting data on BL in Malawi, illustrates the usefulness of a simple aspiration biopsy in the diagnosis of this malignancy by Giemsa staining and also in both types of ISH.<\/jats:p>","DOI":"10.1002\/ijc.2910590503","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:23:52Z","timestamp":1171931032000},"page":"591-596","source":"Crossref","is-referenced-by-count":14,"title":["Correlation between cytopathological results and <i>In situ<\/i> hybridisation on needle aspiration biopsies of suspected african Burkitt's lymphomas"],"prefix":"10.1002","volume":"59","author":[{"given":"Louise G.","family":"Labrecque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin","family":"Lampert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kazembe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Philips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly E.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"97","volume-title":"Burkitt's lymphoma, a human cancer model","author":"Aboulola M.","year":"1985"},{"key":"e_1_2_1_3_1","first-page":"31","volume-title":"Burkitt's lymphoma, a human cancer model","author":"Berard C. W.","year":"1985"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1981.93"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67236-1_14"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.22.8790"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90093-7"},{"key":"e_1_2_1_10_1","first-page":"4253","article-title":"Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein\u2010Barr virus","volume":"41","author":"Hanto D. W.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.23.9006"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803243181203"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.7.616"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.12.1099"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.805"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910130605"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91837-K"},{"key":"e_1_2_1_18_1","first-page":"677","article-title":"Fine needle aspiration cytology of bone lesions. Analysis of a three\u2010year experience in rural Africa","volume":"34","author":"Melkert P. W. J.","year":"1990","journal-title":"Acta Cytol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903163201103"},{"key":"e_1_2_1_20_1","first-page":"87","volume-title":"Burkitt's lymphoma, a human cancer model","author":"Nkrumah F. K.","year":"1985"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260302"},{"key":"e_1_2_1_22_1","first-page":"107","volume-title":"Burkitt's lymphoma, a human cancer model","author":"Philip T.","year":"1985"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-4-276"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06396.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90171-2"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.2.222"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200806"},{"key":"e_1_2_1_28_1","first-page":"64","volume-title":"Burkitt's lymphoma","author":"Wright D. H.","year":"1970"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460509"},{"key":"e_1_2_1_30_1","first-page":"1461","article-title":"Abundant expression of EBER 1 small RNA in nasopharyngeal carcinoma","volume":"138","author":"Wu T. C.","year":"1991","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92740-4"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910590503","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910590503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:26:25Z","timestamp":1698107185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910590503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/ijc.2910590503"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910590503","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}