{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:25:52Z","timestamp":1770719152871,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraperitoneal injection of lymphoid cells from EBV<jats:sup>+<\/jats:sup> donors into SCID mice might provide a useful tool for studying the pathways of B\u2010cell lymphomagenesis in man. Since previous studies showed that donor T cells greatly favor B\u2010cell proliferation and tumor generation in this model, we addressed the host and donor factors involved in limiting or promoting lymphoma development. The number of EBV\u2010infected B\u2010cell precursors was crucial, since purified B lymphocytes, which alone were unable to generate tumors, underwent expansion and established tumor masses when the animals were inoculated with an EBV\u2010containing supernatant. Host factors were critical in limiting tumor development; <jats:italic>in vivo<\/jats:italic> NK\u2010cell removal allowed purified B cells to expand and proceed to tumors in the absence of T lymphocytes, whereas potentiation of mouse NK\u2010cell activity prevented tumor generation in PBMC\u2010 and LCL\u2010injected animals. The T\u2010cell\u2010derived factors that favor lymphomagenesis could not be identified; IL\u20102, IL\u20104, IL\u20106, and soluble CD23 were not able to promote B\u2010cell expansion, and treatment of PBMC\u2010injected mice with the relevant anti\u2010cytokine anti\u2010sera did not counteract lymphoma development. These experiments also showed that IL\u20106 plays a minor role, if any, in B\u2010cell lymphoproliferation in this model. Our data indicate that reconstitution of SCID mice with PBMC from EBV<jats:sup>+<\/jats:sup> donors may constitute a useful model for determining the events involved in lymphomagenesis in humans, provided that strict control of all the experimental variables is guaranteed.<\/jats:p>","DOI":"10.1002\/ijc.2910590516","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:23:52Z","timestamp":1171931032000},"page":"676-683","source":"Crossref","is-referenced-by-count":18,"title":["Lymphoproliferative disease in human peripheral\u2010blood\u2010mononuclear\u2010cell\u2010injected scid mice. II. Role of host and donor factors in tumor generation"],"prefix":"10.1002","volume":"59","author":[{"given":"Arianna","family":"Veronesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Veronese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Menin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"D'Andrea1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Chieco\u2010Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220329"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4049\/jimmunol.146.1.57","article-title":"B\u2010cell activation during HIV\u20101 infection. II. Cell\u2010to\u2010cell interactions and cytokine requirement","volume":"146","author":"Amadori A.","year":"1991","journal-title":"J. Immunol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199107000-00005"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.3995"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114573"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.4049\/jimmunol.148.4.1065","article-title":"Human peripheral\u2010blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies","volume":"148","author":"Carlsson R.","year":"1992","journal-title":"J. Immunol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb05845.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jnci\/54.1.107","article-title":"Immunologic induction of malignant lymphoma: identification of donor and host tumors in the graft\u2010versus\u2010host model","volume":"54","author":"Gleichmann E.","year":"1975","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_10_1","first-page":"915","article-title":"Functional heterogeneity and pathogenic significance of interleukin 6 in B\u2010cell lymphomas","volume":"141","author":"Hsu S.\u2010M.","year":"1992","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91408-E"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-1-113"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.4049\/jimmunol.151.7.3894","article-title":"Specific antibody production to a recall or a neo\u2010antigen by SCID mice reconstituted with human peripheral\u2010blood lymphocytes","volume":"151","author":"Nonoyama S.","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_1","first-page":"2468","article-title":"Heterogeneity among Epstein\u2010Barr\u2010virus\u2010seropositive donors in the generation of immunoblastic B\u2010cell lymphomas in SCID mice receiving human peripheral\u2010blood leukocyte grafts","volume":"52","author":"Picchio G. R.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_1_15_1","first-page":"1187","article-title":"Hemagglutination and graft\u2010versus\u2010host disease in the severe\u2010combined\u2010immunodeficiency mouse lymphoproliferative\u2010disease model","volume":"140","author":"Pirruccello S. J.","year":"1992","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-4-276"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199303000-00007"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.147"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115043"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.61"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232502"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/jvi.64.6.3033-3041.1990","article-title":"Identification of interleukin\u20106 as an autocrine growth factor for Epstein\u2010Barr\u2010virus\u2010immortalized B cells","volume":"64","author":"Tosato G.","year":"1990","journal-title":"J. Virol."},{"key":"e_1_2_1_23_1","first-page":"214s","article-title":"Properties of tumors arising in SCID mice injected with PBMC from EBV\u2010positive donors","volume":"8","author":"Veronese M. L.","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1763"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.4049\/jimmunol.149.8.2830","article-title":"Engraftment of human peripheral\u2010blood leukocytes into severecombined\u2010immunodeficient mice results in the long\u2010term and dynamic production of human xenoreactive antibodies","volume":"149","author":"Williams S. S.","year":"1992","journal-title":"J. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910590516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910590516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:27:33Z","timestamp":1698107253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910590516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["10.1002\/ijc.2910590516"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910590516","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}