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Activation of EBV latent gene expression has been shown to increase the survival of these tumour cells by blocking programmed cell death. To investigate the nature of this protection, we assessed the function of the EBV latent EBNA\u20104 gene in a group 1 lymphoma line, dG75. Group I BL cells induced to undergo apoptosis in response to serum starvation were protected in the presence of EBNA\u20104 protein. A possible factor underlying this EBNA\u20104\u2010associated survival was increased expression of the oncoprotein <jats:italic>bcl\u20102<\/jats:italic>, a known repressor of cell death. Together these data suggest that EBNA\u20104 plays an important role in the regulation of programmed cell death in BL tumour cells. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910600110","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:42:20Z","timestamp":1171932140000},"page":"65-72","source":"Crossref","is-referenced-by-count":28,"title":["Burkitt's lymphoma cells are resistant to programmed cell death in the presence of the epstein\u2010barr virus latent antigen EBNA\u20104"],"prefix":"10.1002","volume":"60","author":[{"given":"Sharon L.","family":"Silins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom B.","family":"Sculley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190105"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/359552a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240305"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90123-T"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1182\/blood.V80.2.459.459","article-title":"Expression of bel\u20102 in Burkitt's Iymphoma cell lines: induction by latent Epstein\u2010Barr virus genes","volume":"80","author":"Finke J.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/349612a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400313"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90007-L"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.6961"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230948"},{"key":"e_1_2_1_12_1","first-page":"5","volume-title":"Apoptosis: the molecular biology of cell death","author":"Kerr J. 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Pathol."},{"key":"e_1_2_1_20_1","first-page":"1495","article-title":"Wild\u2010type p53 induces apoptosis in a Burkitt's Iymphoma (BL) line that carries mutant p53","volume":"8","author":"Ramovist T.","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02568.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1317"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1128\/jvi.66.5.2893-2903.1992","article-title":"Use of second\u2010site homologous recombination to demonstrate that Epstein\u2010Barr virus nuclear antigen 3B is not important for lymphocyte infection or growth transformation. In vitro","volume":"66","author":"Tomkinson B.","year":"1992","journal-title":"J. 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