{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:00:08Z","timestamp":1765666808157},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4189,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cohort of 5,546 ulcerative colitis patients was identified from the Danish Hospital Discharge Register for 1977\u20131989. Patients not included in the cohort comprised those with proctitis, those treated in outpatient clinics and those for whom follow\u2010up was less than 1 year. The cohort was linked to the Danish Cancer Registry in order to assess the risks for colorectal and other cancers. The linkage revealed a significant increase in the number of colorectal cancers over that in the general population (RR = 1.8; n = 42; 95% CI = 1.3\u20132.4) with consistent relative risks during early and late follow\u2010up. The relative risk was considerably higher among younger (20\u201339 years: RR = 22; n = 8; 95% CI = 9.7\u201344) than older patients (\u226560 years: RR = 1.3; n = 25; 95% CI = 0.8\u20131.9), but the risk difference between patients and the general population was approximately constant across all ages. In addition, we observed a significant increase in the relative risk of hepatobiliary cancers (RR = 2.3; n = 9; 95% = 1.0\u20134.3) and a slight but significant increase in the relative risk of non\u2010melanoma skin cancer (RR = 1.4; n = 37; 95% CI = 1.0\u20131.9). In summary, our population\u2010based study confirms the increased risk of colorectal cancer among patients with ulcerative colitis and provides new leads suggesting that hepatobiliary cancer and non\u2010melanoma skin cancer should be considered as possible sites for future patient monitoring. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910600309","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T15:03:51Z","timestamp":1222268631000},"page":"330-333","source":"Crossref","is-referenced-by-count":93,"title":["Cancer in patients with ulcerative colitis"],"prefix":"10.1002","volume":"60","author":[{"given":"Lene","family":"Mellemkjaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jsorgen H.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gridley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709011139"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6774.437"},{"key":"e_1_2_1_4_1","volume-title":"Classification of surgical procedures and therapies","author":"Danish National Board of Health","year":"1973"},{"key":"e_1_2_1_5_1","volume-title":"Classification of diseases","author":"Danish National Board of Health","year":"1976"},{"key":"e_1_2_1_6_1","volume-title":"The activity in the hospital care system","author":"Danish National Board of Health","year":"1981"},{"key":"e_1_2_1_7_1","first-page":"1174","article-title":"Pericholangitis and sclerosing cholangitis are risk factors for dysplasia and cancer in ulcerative colitis","volume":"88","author":"D'Haens G. R.","year":"1993","journal-title":"Amer. J. Gastroenterol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231802"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90202-V"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910401)67:7<2015::AID-CNCR2820670731>3.0.CO;2-R"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90541-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851215)56:12<2914::AID-CNCR2820561232>3.0.CO;2-J"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171048"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.2.206"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909093080"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91163-X"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529108998621"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90058-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240501109"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1569::AID-CNCR2820580731>3.0.CO;2-U"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.39.020188.000431"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.6.490"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02139219"},{"key":"e_1_2_1_24_1","series-title":"DHHS Publication No (NIH) 79\u20101649","volume-title":"Epidemiologic analysis with a programmable calculator","author":"Rothman K. J.","year":"1979"},{"key":"e_1_2_1_25_1","volume-title":"Cancer incidence in Denmark 1989","author":"Storm H. H.","year":"1992"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80158-1"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910600309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910600309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:56:08Z","timestamp":1698360968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910600309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,27]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,1,27]]}},"alternative-id":["10.1002\/ijc.2910600309"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910600309","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1,27]]}}}