{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:52:23Z","timestamp":1791280343944,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4190,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The new photosensitizer, meso\u2010tetrahydroxyphenylchlorin (mTPHC) was compared with Photofrin in the murine RIF1 tumour and in normal mouse skin. A range of mTHPC or Photofrin doses were given at intervals of 1 hr to 7 days before illumination. mTHPC\u2010PDT resulted in much higher tumour phototoxicity with longer regrowth delays and more cures. The RIFI tumour could be effectively treated with 30 J cm<jats:sup>\u22121<\/jats:sup> (interstitial illumination) at 1 day after mTHPC, whereas 4 to 13 times higher light doses were required with Photofrin for an equivalent anti\u2010tumour effect. High doses of mTHPC also caused more skin phototoxicity (superficial illumination) than Photofrin for the 1\u2010day illumination interval. Evaluating both tumour and normal skin photosensitization, the largest therapeutic gain factor (TGF) for mTHPC\u2010PDT was achieved with a low drug dose (0.15 mg kg<jats:sup>\u22121<\/jats:sup>) at 1 day before illumination (TGF = 5.6, relative to Photofrin PDT). The duration of cutaneous photosensitivity for mTHPC was shorter than for Photofrin. The light dose required to produce a desquamation response in 50% of the animals increased more than 20\u2010fold over the period 1 to 7 days after high doses of mTHPC, whereas this light dose only increased by a factor of 2 from 1 to 7 days after Photofrin. The large therapeutic gains seen for mTHPC\u2010mediated PDT compared to Photofrin, plus the rapid fading of skin photosensitization, suggest that mTHPC is a potent photosensitizer suitable for clinical testing. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910600320","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T00:30:48Z","timestamp":1277512248000},"page":"388-394","source":"Crossref","is-referenced-by-count":55,"title":["Photosensitizing efficacy of MTHPC\u2010PDT compared to Photofrin\u2010PDT in the RIF1 mouse tumour and normal skin"],"prefix":"10.1002","volume":"60","author":[{"given":"Ingrid P. J.","family":"van Geel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Oppelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne G.","family":"Oussoren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A. Der","family":"Van Valk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona A.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1988.tb02769.x"},{"key":"e_1_2_1_3_1","first-page":"441","volume-title":"Photodynamic therapy and biomedical lasers","author":"Allen R. P.","year":"1992"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560621"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90394-B"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.232"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2610277"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.412"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900100514"},{"key":"e_1_2_1_10_1","first-page":"3985","article-title":"Tissue distribution and photosensitizing properties of mono\u2010L\u2010aspartyl chlorin e6 in a mouse tumor model","volume":"30","author":"Gomer C. J.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","first-page":"572","article-title":"Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy","volume":"45","author":"Henderson B. W.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","first-page":"4642","article-title":"Probing the structure and stability of the tumor\u2010localizing derivative of hematoporphyrin by reduction with LiAlH4","volume":"47","author":"Kessel D.","year":"1987","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","first-page":"459","volume-title":"Photodynamic therapy and biomedical lasers","author":"Lui H.","year":"1992"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570618"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19920001377"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.474"},{"key":"e_1_2_1_17_1","first-page":"421","volume-title":"Clinical evaluation of photodynamic therapy and biomedical lasers","author":"Ris H. B.","year":"1992"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530126"},{"key":"e_1_2_1_19_1","volume-title":"Proceedings Biomedical Optics Europe","author":"Savary J. F.","year":"1993"},{"key":"e_1_2_1_20_1","first-page":"2532","article-title":"Destruction of rat mammary tumor and normal tissue microcirculation by hematoporpyrin derivative photo\u2010irradiation observed in vivo in sandwich observation chambers","volume":"46","author":"Star W. M.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1989.tb04111.x"},{"key":"e_1_2_1_22_1","first-page":"594","article-title":"A new mouse tumor model system (RIF\u20101) for comparison of end\u2010point studies","volume":"64","author":"Twentyman P. R.","year":"1980","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_23_1","first-page":"441","volume-title":"Photodynamic therapy and biomedical lasers","author":"Volz W.","year":"1992"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910600320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910600320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:56:13Z","timestamp":1698360973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910600320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,27]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,1,27]]}},"alternative-id":["10.1002\/ijc.2910600320"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910600320","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1,27]]}}}