{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:47:54Z","timestamp":1783633674283,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental studies have shown that the 67\u2010kDa laminin receptor (LRec) is an important molecule for the interaction of tumour cells with the extracellular matrix, and that it plays a role in the early steps of angiogenesis and in tumour invasion and metastasis. We performed a multi\u2010parametric study in 171 node\u2010negative breast cancers, followed for a median time of 6 years, to verify whether determination of the LRec provides prognostic information in addition to intra\u2010tumoral microvessel density (IMD), a measure of tumour angiogenesis, and to other biological and conventional indicators. A positive association between LRec expression and high neovascularization was found, although it did not reach significance. LRec was not associated either with other biological markers (oestrogen receptor, progesterone receptor and <jats:italic>p53<\/jats:italic> expression) or to the conventional prognostic features [menopausal status, tumour size, histological types, grading and peri\u2010tumoral lymphatic vessel invasion (PLVI)]. In univariate analysis, IMD, <jats:italic>p53<\/jats:italic>, PgR, PLVI, grading and tumour size were significant prognostic indicators of relapse\u2010free survival (RFS). LRec expression approached significance when considered as a dichotomous variable, after having selected the optimum cutoff of 10% to distinguish high\u2010risk from low\u2010risk patients. For overall survival (OS), tumour size and IMD (continuous variable) were significant prognostic factors, and <jats:italic>p53<\/jats:italic> approached significance. In multivariate analysis for RFS, the joint variable LRec and vascularization was the strongest independent prognostic factor, followed by PgR, PLVI and <jats:italic>p53<\/jats:italic>. For OS, tumour size was the only independent prognostic indicator in this series.<\/jats:p>","DOI":"10.1002\/ijc.2910600506","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:38:53Z","timestamp":1171931933000},"page":"604-610","source":"Crossref","is-referenced-by-count":55,"title":["67\u2010kDa laminin\u2010receptor expression adds prognostic information to intra\u2010tumoral microvessel density in node\u2010negative breast cancer"],"prefix":"10.1002","volume":"60","author":[{"given":"Giampietro","family":"Gasparini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Barbareschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Boracchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Picrantonio","family":"Bevilacoua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Verderio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Dalla","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4348-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(77)90141-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2347295"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90189-K"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1957.43"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90344-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197507)36:1<1::AID-CNCR2820360102>3.0.CO;2-4"},{"key":"e_1_2_1_9_1","first-page":"65","article-title":"The role of antigenesis in tumor growth","volume":"3","author":"Folkman J.","year":"1992","journal-title":"Semin. 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