{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:29:01Z","timestamp":1791080941215,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell leukemia virus type 1 (HTLV\u2010I) is etiologically associated with adult T\u2010cell leukemia\/lymphoma (ATL). The prototypic HTLV\u2010I, ATK, is the only full\u2010length provirus cloned from uncultured leukemic cells and completely sequenced prior to this study. We have determined the complete nucleotide sequence of another full\u2010length HTLV\u2010I provirus cloned directly from leukemic cells. A premature termination codon was found in the second open reading frame (orf II) of the pX region. Our finding indicates that open reading frame II of the HTLV\u2010I pX region is not required for outgrowth of ATL leukemic clones <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910600522","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:38:53Z","timestamp":1171931933000},"page":"701-706","source":"Crossref","is-referenced-by-count":32,"title":["Nucleotide sequence analysis of a full\u2010length human T\u2010cell leukemia virus type I from adult T\u2010cell leukemia cells: A prematurely terminated PX open reading frame II"],"prefix":"10.1002","volume":"60","author":[{"given":"Kuan","family":"S.Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Okayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun\u2010Hou","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Essex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2843985"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3005"},{"issue":"3","key":"e_1_2_1_4_1","first-page":"67S","article-title":"cDNA sequencing confirms HTLV\u2010I expression in adult T\u2010cell leukcmia\/lymphoma and different sequence variations in vivo and. In vitro","volume":"6","author":"Berneman Z. N.","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1450"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1993.9.1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1128\/jvi.66.3.1737-1745.1992","article-title":"Complex splicing in the human T\u2010cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I","volume":"66","author":"Ciminale V.","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/305060a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90754-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1992.8.1201"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(90)90052-R"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.2.1015-1023.1993"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3351"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90498-G"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1857968"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2888191"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.13.5754"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04583.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/jvi.65.7.3770-3778.1991","article-title":"in vivo genetic variability of human T\u2010cell leukemia virus type I depends more upon geography than upon pathologies","volume":"65","author":"Komurian F.","year":"1991","journal-title":"J. Virol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8813"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1128\/jvi.67.4.2360-2366.1993","article-title":"The p121. p1311 and p30ii proteins encoded by human T\u2010cell leukemia\/Tymphotropic virus type I open reading frames I and 11 are localized in three different cellular compartments","volume":"67","author":"Koralnik I. J.","year":"1993","journal-title":"J. Virol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1128\/jvi.65.10.5471-5476.1991","article-title":"Polymerase chain reaction analysis of defective human T\u2010cell leukemia virus tvpe I proviral genomes in leukemic cells of patients with adult T\u2010cell leukemia","volume":"65","author":"Korber B.","year":"1991","journal-title":"J. Virol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92322-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089350"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-7-1695"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1128\/jvi.65.6.3349-3353.1991","article-title":"Transgenic thymocytes are refractory to transformstion by the human T\u2010cell leukemia virus type I tax gene","volume":"65","author":"Nerenberg M. I.","year":"1991","journal-title":"J. Virol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90654-T"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1128\/jvi.66.10.5879-5889.1992","article-title":"Mapping of homologous, amino\u2010terminal neutralizing regions of human T\u2010cell Iymphotropic virus type I and II gp46 envelope glycoproteins","volume":"66","author":"Palker T. J.","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/jvi.54.3.781-790.1985","article-title":"Nucleotide sequence analysis of a variant human T\u2010cell leukemia virus (HTLV\u2010Ib) provirus with a deletion in pX\u2010I","volume":"54","author":"Ratner L.","year":"1985","journal-title":"J. Virol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","unstructured":"Renjifo B. Osterman J. Borrera I.andEssex M. Nucleotide sequences of HTLV\u2010I from a family cluster with tropical spastic paraparesis\/HTLV\u2010I associated myelopathy. Res. Virol (1995). (In press)","DOI":"10.1016\/0923-2516(96)81078-8"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2838905"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2448875"},{"key":"e_1_2_1_33_1","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook J.","year":"1989"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90418-B"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/309640a0"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_1_38_1","first-page":"59","volume-title":"Acquired Immune Deficiency Syndrome","author":"Shaw G. M.","year":"1984"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6089351"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.11.1875"},{"key":"e_1_2_1_41_1","first-page":"29","article-title":"Nucleotide sequence analysis of a provirus derived from HTLV\u20101 \u2010associated myelopathy (HAM)","volume":"5","author":"Tsujimoto A.","year":"1988","journal-title":"Mol. Biol Med."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9733"},{"key":"e_1_2_1_43_1","first-page":"159","article-title":"Molecular biology of human T\u2010cell leukemia virus associated with adult T\u2010cell leukemia","volume":"115","author":"Yoshida M.","year":"1985","journal-title":"Curr. Top. Microbiol Immunol."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2534"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910600522","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910600522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T17:57:38Z","timestamp":1698256658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910600522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,3]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,3,3]]}},"alternative-id":["10.1002\/ijc.2910600522"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910600522","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3,3]]}}}