{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:39:53Z","timestamp":1789940393067,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell malignancies in Brazil have a high seroprevalence rate of HTLV\u2010I antibodies. We have analyzed the disease features in 188 Brazilian patients with a T\u2010cell disorder. These included 40 with T\u2010lymphoblastic leukaemia or lymphoma (T\u2010ALL\/T\u2010LbLy) and 148 with mature T\u2010cell diseases: 5 T\u2010prolymphocytic leukaemia, 53 adult T\u2010cell leukaemia\/lymphoma (ATLL), 54 cutaneous T\u2010cell lymphomas, 29 pleomorphic T\u2010cell lymphomas and 7 large granular lymphocyte leukaemia. The diagnosis was based on clinical, morphological and immunological features and HTLV\u2010I serology. ATLL in Brazil has the same disease features as in other endemic regions, the only apparent differences being: age, Brazilian patients being younger than Japanese, and ethnic grouping, one third of Brazilians being white Caucasians of European descent. We applied a scoring system based on the presence or absence of typical features associated with ATLL: hypercalcaemia, cell morphology, immunophenotype, histopathology and HTLV\u2010I status, to see whether it may help in diagnosing cases of ATLL. All had high scores, whereas all other T\u2010cell diseases scored low. Only 5 ATLL cases were HTLV\u2010Inegative by serology, but they had otherwise typical features of ATLL, and their cells did not have HTLV\u2010I proviral sequences by DNA analysis. Such cases suggest that ATLL may develop in a minority of individuals living in regions where it is endemic, without evidence of HTLV\u2010I infection, and that other factors may contribute to the pathogenesis of the disease.<\/jats:p>","DOI":"10.1002\/ijc.2910600617","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:38:49Z","timestamp":1171931929000},"page":"823-827","source":"Crossref","is-referenced-by-count":52,"title":["T\u2010cell malignancies in Brazil. Clinico\u2010pathological and molecular studies of HTLV\u2010I\u2010positive and \u2010negative cases"],"prefix":"10.1002","volume":"60","author":[{"given":"Maria S. Pombo","family":"De Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio","family":"Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline D.","family":"Reaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"251","volume-title":"Human retrovirology: HTLV","author":"Blattner W. 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