{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:49:35Z","timestamp":1791067775924,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4117,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that a carcinogenic effect can be transmitted from female mice exposed prenatally to diethylstil\u2010bestrol (DES) to their female offspring. Furthermore, male mice exposed pre\u2010natally to DES can transmit a carcinogenic effect to their offspring through their germ cells. To study how multi\u2010generational carcinogenesis is transmitted through females exposed pre\u2010natally to DES. the technique of blastocyst transfer was utilized. Blastocysts from strain CD\u20101 mice exposed pre\u2010natally to vehicle were transferred to mice exposed pre\u2010natally to DES. Among 143 offspring from these transfers, there were 10 ovarian adenomas and 10 uterine adenocarcino\u2010mas. Among 92 offspring from blastocyst transfers between mice exposed pre\u2010natally to vehicle only, there was 1 ovarian adenoma and 1 uterine adenocarcinoma. Thus the pre\u2010natal exposure of the host to DES produced a maternal environment which increased the incidence of ovarian and uterine tumors. The reverse type of transfer was also performed, in which blastocysts from female mice exposed pre\u2010natally to DES were transferered into mice exposed to vehicle only pre\u2010natally. Among 99 offspring derived from DES\u2010exposed germ cells, 6 developed ovarian adenomas and 16 developed uterine adeno\u2010carcinomas. Thus DES also has a multi\u2010generational effect transmitted through the blastocyst, which is consistent with fetal germ cell mutation from DES. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610218","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:38:38Z","timestamp":1171931918000},"page":"249-252","source":"Crossref","is-referenced-by-count":28,"title":["Multi\u2010generational carcinogenesis from diethylstilbestrol investigated by blastocyst transfers in mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Bruce E.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(83)90181-1"},{"key":"e_1_2_1_3_1","first-page":"1","volume-title":"Ultrasonography in obstetrics and gynecology","author":"Callen P. W.","year":"1988"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64430-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90103-J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod45.4.649"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"16847","DOI":"10.1016\/S0021-9258(19)84783-X","article-title":"Mechanism of genotoxicity of diethylstilbestrolin vivo","volume":"264","author":"Gladek A.","year":"1989","journal-title":"J. biol. Chem."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(79)90122-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420450107"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810715)48:1 <484::AID-CNCR2820481308>3.0.CO;2-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90293-9"},{"key":"e_1_2_1_12_1","volume-title":"Manipulating the mouse embryo. A laboratory manual","author":"Hogan B.","year":"1986"},{"key":"e_1_2_1_13_1","first-page":"46","volume-title":"Diagnostic ultrasound","author":"Hughey M. J.","year":"1987"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53705-4"},{"key":"e_1_2_1_15_1","first-page":"385","volume-title":"Pathology of tumours in laboratory animals","author":"Lemon P. G.","year":"1979"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90482-H"},{"key":"e_1_2_1_17_1","first-page":"353","article-title":"A simple technique for nonsurgical embryo transfer in mice","volume":"29","author":"Moler T. L.","year":"1979","journal-title":"Lab. Animal Sci."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/296575a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.10.753"},{"key":"e_1_2_1_20_1","first-page":"687","article-title":"The fate of diethylstilbestrol in the pregnant mouse","volume":"197","author":"Shah H. C.","year":"1976","journal-title":"J. Pharm. exp. Therap."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090760105"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90227-2"},{"key":"e_1_2_1_23_1","series-title":"IARC Scientific Publications 96","first-page":"1","volume-title":"Perinatal and multigeneration carcinogenesis","author":"Tomatis L.","year":"1989"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.2.145"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500126"},{"key":"e_1_2_1_26_1","first-page":"477","article-title":"Uterine tumors in old female mice exposed prenatally to diethylstilbestrol","volume":"70","author":"Walker B. E.","year":"1983","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_27_1","first-page":"133","article-title":"Tumors in female offspring of mice exposed prenatally to diethylstilbestrol","volume":"73","author":"Walker B. E.","year":"1984","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_28_1","series-title":"IARC Scientific Publications 96","first-page":"349","volume-title":"Perinatal and multigeneration carcinogenesis","author":"Walker B. E.","year":"1989"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635589209514183"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.929839"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910610218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910610218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T22:32:31Z","timestamp":1698359551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910610218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,4,10]]}},"alternative-id":["10.1002\/ijc.2910610218"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910610218","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4,10]]}}}