{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:49:46Z","timestamp":1770702586294,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4093,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that interferon\u2010\u03b1 (IFN\u2010\u03b1) can repress apoptosis in Burkitt lymphoma (BL) cells. In this study, we have compared this protective response with a further, well\u2010established effect of IFN\u2010\u03b1 on BL cells, that of growth arrest. Of a panel of BL lines comprising (<jats:italic>i<\/jats:italic>) EBV\u2010positive and \u2010negative lines that retain the phenotype of the parental tumour cells and (<jats:italic>ii<\/jats:italic>) the prototype IFN\u2010\u03b1\u2010growth\u2010inhibited line, Daudi, only Daudi cells were found to undergo substantial growth inhibition in response to the cytokine. By contrast, all lines, with the notable exception of Daudi, were protected by IFN\u2010\u03b1 from high\u2010rate apoptosis initiated by the Ca<jats:sup>2+<\/jats:sup> ionophore ionomycin. lonomycin failed to elicit an IFN\u2010\u03b1\u2010repressible apoptotic response in either wild\u2010type Daudi cells or IFN\u2010resistant sublines that were refractory to the growth\u2010arresting effects of the cytokine. Analysis of c\u2010myc protein levels confirmed previous observations that repression of apoptosis in IFN\u2010\u03b1\u2010rescuable BL cells was associated with an early inhibition of myc that was followed by a return to high\u2010level expression. Significantly, ionomycin alone induced a comparable transient inhibition of myc protein in Daudi cells. In Daudi cells, but not in IFN\u2010\u03b1\u2010rescuable BL cells, renewed expression of myc observed after the early, transient down\u2010regulation was followed by sustained down\u2010regulation of the protein, which paralleled growth arrest. Our results indicate that long\u2010term growth arrest and repression of apoptosis in BL are distinct cellular responses to IFN\u2010\u03b1. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610313","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:53:03Z","timestamp":1171932783000},"page":"348-354","source":"Crossref","is-referenced-by-count":18,"title":["Effects of interferon\u2010\u03b1 on human b cells: Repression of apoptosis and prevention of cell growth are independent responses of burkitt lymphoma lines"],"prefix":"10.1002","volume":"61","author":[{"given":"Anne E.","family":"Milner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger J. 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