{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:17Z","timestamp":1761058637773},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4092,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome lq abnormalities represent the second most frequent cytogenetic lesion of Burkitt lymphoma (BL) and acute lymphoblastic leukemia (ALL)\u2010L3. The most frequent change is partial duplication of the long arm of chromosome l, involving variable bands but consistently including 1q23. Among AIDS\u2010related BL similar chromosome 1q abnormalities have also been found. We have now characterized in detail the chromosome 1q abnormalities of 4 AIDS\u2010BL cell lines and compared them to other molecular features of the tumor clone, namely infection by Epstein Barr virus (EBV). Immunophenotypic characteristics were also assessed by conventional <jats:italic>in situ<\/jats:italic> immunocytochemical and flow cytometric procedures. The B\u2010cell origin of all cell lines was demonstrated by the expression of B\u2010cell\u2010restricted markers (e.g., CD 19). Analysis of 1g light chains confirmed their monoclonal nature. The t(8; 14) was present in 3 of the 4 lines, whereas variant translocation t(8;22) was detected in the remaining cell line. Additional chromosomal changes were found in all cases, with chromosome 1 being involved in all. Structural changes encompassed in each case the 1q21\u201425 bands, in either duplication or partial trisomy. EBER ISH studies identified EBV association in 3 of the 4 AIDS\u2010BL cell lines in contrast to previous studies of BL of immunocompetent individuals. Our findings of a high frequency of chromosome 1q abnormalities in EBV\u2010infected AIDS\u2010related BL cell lines demonstrate that such chromosomal abnormality and EBV positivity are not mutually exclusive and are possibly independent factors, whereas their close association in AIDS may be related to the immunodeficiency. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610316","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:53:03Z","timestamp":1171932783000},"page":"370-374","source":"Crossref","is-referenced-by-count":15,"title":["High frequency of EBV association with non\u2010random abnormalities of the chromosome region 1q21\u201025 in aids\u2010related Burkitt's lymphoma\u2010derived cell lines"],"prefix":"10.1002","volume":"61","author":[{"given":"Pietro","family":"Polito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Cilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annunziata","family":"Gloghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Cozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Perin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"De Paoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.5.1289.1289"},{"key":"e_1_2_1_3_1","first-page":"104","volume-title":"Chromosomes in hematology","author":"Berger R.","year":"1986"},{"key":"e_1_2_1_4_1","first-page":"143","article-title":"Existe\u2010t\u2010il une \u00e9quivalence fonction\u2010nelle entre anomalies du bras long du chromosome 1 et pr\u00e9sence du virus d'Epstein\u2010Barr dans les lign\u00e9es continues de lymphome de Burkitt?","volume":"298","author":"Berger R.","year":"1984","journal-title":"C.R. 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