{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:56:33Z","timestamp":1790970993064,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4080,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,5,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>E\u2010selectin is an adhesion molecule of endothelial cells that binds to cancer cells mediated by sialyl Lewis A (sLe<jats:sup>a<\/jats:sup>) or sialyl Lewis X (sLe<jats:sup>x<\/jats:sup>). It is suspected to be involved in hematogenous metastasis of tumors. Therefore, it is worth examining E\u2010selectin expression in human colorectal cancer and its hepatic metastasis. In the present study, E\u2010selectin was clearly revealed on the endothelial cells of small vessels adjacent to cancer nests both in primary and in metastatic nests in immunohistochemistry. In these tissues, E\u2010selectin was observed on the endothelial cells lining the lumen of small vessels. Its expression adjacent to cancer nests appears to be induced through some stimuli by cancer cells, since its degree of expression is inversely correlated to the distance of the blood vessels from the cancer nests (<jats:italic>p<\/jats:italic> &lt; 0.001). Endothelial cells adjacent to the metastatic lesion expressed E\u2010selectin more extensively than those adjacent to the primary foci. This is also in line with the finding on serum E\u2010selectin levels which were significantly elevated in the metastatic group as compared with the non\u2010metastatic group. The serum E\u2010selectin level may provide useful information in the diagnosis for hepatic metastasis of colorectal cancer, although the results are still tentative. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610404","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:50:27Z","timestamp":1171932627000},"page":"455-460","source":"Crossref","is-referenced-by-count":75,"title":["Expression of E\u2010selectin on endothelial cells of small veins in human colorectal cancer"],"prefix":"10.1002","volume":"61","author":[{"given":"Chunlin","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Kiriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Mistuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiji","family":"Kannagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195406000-00015"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9238"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2466335"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.1.4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00916897"},{"key":"e_1_2_1_8_1","first-page":"6883","article-title":"Increased expression of sialyldimeric Le x antigen in liver metastases of human colorectal carcinoma","volume":"49","author":"Hoff S. 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