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Mutations were identified by polymerase chain reaction amplification and direct sequencing in 50% of the specimens. Eleven tumors harbored a single base\u2010pair substitution leading to either an amino\u2010acid substitution (8 tumors) or a chain\u2010termination signal (3 tumors), and one tumor revealed a 15\u2010bp deletion in exon 7 with a silent base substitution adjacent to the deletion site. Mutations occurred in all 4 exons examined, with a preponderance in exon 5. Of the 6 mutations identified among the 14 adenocarcinomas examined, 3 were G to T transversions, a mutation that has thus far been absent from reported mutations in Barrett's esophageal adenocarcinomas and dysplasias from patients residing in Europe and North America. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610505","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:52:13Z","timestamp":1171932733000},"page":"611-614","source":"Crossref","is-referenced-by-count":22,"title":["<i>p53<\/i> mutations in esophageal tumors from high\u2010incidence areas of China"],"prefix":"10.1002","volume":"61","author":[{"given":"Yuan\u2010Yuan","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuncion","family":"Est\u00e8ve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghyslaine","family":"Martel\u2010Planche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Hsin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Montesano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Hollstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10124"},{"key":"e_1_2_1_3_1","first-page":"4495","article-title":"p53 gene mutations in Barrett's epithelium and esophageal cancer","volume":"51","author":"Casson A. 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