{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:21:17Z","timestamp":1791220877911,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4068,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five monoclonal antibodies detected a surface antigen expressed exclusively on T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) in a panel of 45 human hematopoietic cell lines, including T\u2010cell lines derived from adult T\u2010cell leukemia and those established by immortalization with human T\u2010cell leukemia virus type 1 or <jats:italic>Herpesvirus saimiri.<\/jats:italic> Peripheral blood mono\u2010nuclear cells, including fresh and activated T cells, were also completely devoid of this antigen. We designated this antigen as TALLA\u20101 (from T\u2010ALL\u2010associated antigen 1). By expression cloning, a cDNA clone encoding TALLA\u20101 was isolated from T\u2010ALL cell line Molt\u20104. TALLA\u20101 was found to be a member of the transmembrane 4 superfamily (TM4SF). The cDNA was also essentially identical to A15, which was isolated from another T\u2010ALL cell line, HPB\u2010ALL, by differential hybridization with normal peripheral blood lymphocytes, and to CCG\u2010B7, which was isolated from a brain cDNA library using CCG repeat as a probe. The gene product was now characterized in detail at the protein level. Northern blot analysis showed that the gene was expressed most strongly in brain, skeletal muscle and spleen. In a panel of 52 non\u2010hematopoietic human cell lines, the majority of neuroblastoma cell lines were found to be positive for TALLA\u20101. Like ME491, CO\u2010029 and L6, TALLA\u20101 may be another TM4SF member behaving as a potential tumor\u2010associated antigen. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610519","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:52:13Z","timestamp":1171932733000},"page":"706-715","source":"Crossref","is-referenced-by-count":54,"title":["Identification of a highly specific surface marker of T\u2010cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily"],"prefix":"10.1002","volume":"61","author":[{"given":"Shin","family":"Takagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomi","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fukudome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Minegishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuke","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorio","family":"Hinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188787"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3116"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.9.2841"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191884"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/314053a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.23.8998"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520316"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1128\/jvi.66.3.1394-1401.1992","article-title":"Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T\u2010cell leukemia virus type 1 (HTLV\u20101)\u2010induced syncytium formation: altered glycosylation of C33 antigen in HTLV\u20101\u2010positive T cells","volume":"66","author":"Fukudome K.","year":"1992","journal-title":"J. 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