{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:27:30Z","timestamp":1791066450405,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4032,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple primary cancers in the same individual occur rarely. Consequently, a large number of cancer patients have to be followed for long periods to obtain adequate information about their risk of subsequent tumour development. Studies of multiple malignancies are of interest, since they may provide information on common or opposite risk factors. In the present study, the risk of second primary cancers following carcinoma in situ of the uterine cervix diagnosed in Norway in the period 1970\u20131992 was examined and quantified. Altogether, 37,001 patients with carcinoma m <jats:italic>situ<\/jats:italic> were followed from the date of diagnosis until 31 December 1992. The follow\u2010up period was divided into 5\u2010year intervals. The results were expressed as standardized incidence ratios (SIR = O\/E), and their 95% confidence intervals were given. A total of 1,037 second primary cancers in 989 individuals were identified. There was no overall excess of second primary cancers. However, there were differences depending on the site: cancers of the oesophagus, nose, nasal cavities, trachea, bronchus, lung, vulva, vagina, bladder and other urinary organs, and other skin cancers, excluding basal\u2010cell carcinoma, occurred more frequently. A lower risk than expected was noted for cancer of the cervix uteri and cancer of the corpus uteri. There was a rising trend with time in the observed\/expected ratio for cancer of urinary organs. In the group of patients evaluated, the likelihood of subsequent tumour development was no greater than in the general female population. Nevertheless, cancer sites of higher and of lower risk than expected were identified among the carcinoma\u2010<jats:italic>In situ<\/jats:italic> patients. \u00a9 1995 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:49:48Z","timestamp":1171932588000},"page":"29-33","source":"Crossref","is-referenced-by-count":29,"title":["Second primary cancers in patients with carcinoma <i>in situ<\/i> of the uterine cervix. The norwegian experience 1970\u20131992"],"prefix":"10.1002","volume":"62","author":[{"given":"Tone","family":"Bj\u00f8rge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin M.","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry B.","family":"Skare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odd","family":"S\u00f8reide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar \u00d8.","family":"Thoresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90224-4"},{"key":"e_1_2_1_2_1","first-page":"955","article-title":"35 others, Second cancers following radiation treatment for cervical cancer. 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S.","year":"1992","journal-title":"Amer. J. Epidemiol"},{"key":"e_1_2_1_14_1","first-page":"204","article-title":"Differences in the occurrence and age distribution of lesions in other organs in women with\/without cervical neoplasia","volume":"9","author":"Sandstad E.","year":"1988","journal-title":"Europ. J. Gynaec. Oncol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00051317","article-title":"Cutaneous melanoma following cervical intra\u2010epithelial neoplasia in western Washington State","volume":"4","author":"Shmulewitz E. 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