{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:10:17Z","timestamp":1695877817889},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4031,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mononuclear cells from the peripheral blood of patients with systemic lupus erythematosus (SLE) were transformed with the Epstein\u2010Barr virus (EBV) and the resultant polyclonal B\u2010lymphoblastoid cell lines were tested for antibody activity to membrane antigens of certain T\u2010cell lines. B lymphoblastoid cell lines secreting specific antibodies were fused with (mouse x human) heteromyeloma SHM\u2010D33 cells. Among the large number of hybridomas generated, one which produced a human monoclonal antibody (MAb) TONO\u2010I (1gM, \u03bb) was selected. MAb TONO\u2010I proved to be reactive with 4 human T\u2010cell lines, HPB\u2010MLT, L\u2010MAT, MOLT\u20103 and MOLT\u20104F, but not with B\u2010leukemia, Burkitt's lymphoma, myelomonocytic leukemia, erythroleukemia or non\u2010hematopoietic malignant cell lines. MAb TONO\u2010I reacted positively with fresh leukemia cells from 2 of 7 patients with acute T\u2010lymphocytic leukemia, but no reaction was observed in non\u2010T\u2010cell leukemia cases. Normal lymphocytes, monocytes, granulocytes, red blood cells and platelets in the peripheral blood did not demonstrate remarkable binding. Neither thymocytes nor bone\u2010marrow cells from healthy volunteers were reactive. The antigens defined by MAb TONO\u2010I were polypeptides of 57 kDa and 68 kDa. Immunohistological studies revealed no staining of thymocytes in the thymus of a 6\u2010month\u2010old child, but showed epithelial reticular cells and Hassall's corpuscles to stain positively. These results suggest that MAb TONO\u2010I is directed to T\u2010leukemic cells and some components of thymus tissue. \u00a9 1995 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620110","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:49:48Z","timestamp":1171932588000},"page":"42-47","source":"Crossref","is-referenced-by-count":3,"title":["A novel human monoclonal antibody, TONO\u20101, reactive with T\u2010lymphocytic leukemia cells"],"prefix":"10.1002","volume":"62","author":[{"given":"Muneo","family":"Numasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaaki","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakichi","family":"Motomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nukiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(87)90051-4"},{"key":"e_1_2_1_2_1","first-page":"7.1.1","volume-title":"Current protocols in immunology","author":"Coligan J. 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