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The maximum enhancement was seen on the 15th day of pregnancy. The incidence of pulmonary metastasis returned to the level observed in non\u2010pregnant mice when the cells were injected 4 days after parturition. Pregnancy also significantly increased the incidence of pulmonary metastasis of 2 other cell lines (3LL and Colon 26). Injection of G6 cells after hysterectomy performed on the 15th day of pregnancy resulted in decreased lung colonization, similar to that seen after parturition. Quantificative analysis of the arrest of G6 cells labeled with [<jats:sup>125<\/jats:sup>1]\u20105\u2010iodo\u20102\u2032\u2010deoxyuridine in the lungs showed that the tumor\u2010cell clearance from the lungs during the 24\u201372 hr after tumor\u2010cell injection was much slower in pregnant than in non\u2010pregnant mice. The continuous administration of \u03b2\u2010estradiol and\/or progesterone, which maintained serum levels of the hormones equivalent to those prevailing on the 15th day of pregnancy, did not affect the lung colonization of G6 cells. Tumor\u2010cell\u2010platelet aggregation was more extensive with platelets obtained from mice at the 15th day of pregnancy than with those from non\u2010pregnant mice. When platelets isolated from pregnant mice were injected into normal mice 5 min before G6 injection, lung metastasis was also enhanced. These findings suggest that a pregnant host is handicapped with regard to pulmonary metastasis, this being partly due to increased platelet\u2010aggregating activity in response to tumor cells. \u00a9 1995 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620314","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:47:36Z","timestamp":1171932456000},"page":"314-318","source":"Crossref","is-referenced-by-count":5,"title":["Increased experimental pulmonary metastasis in pregnant mice"],"prefix":"10.1002","volume":"62","author":[{"given":"Hajime","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Tanigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Matsuhisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Akedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-32-5-619"},{"key":"e_1_2_1_2_1","first-page":"134","article-title":"Potentiation and inhibition of tumor cell invasion by host cells and mediators","volume":"9","author":"Akedo H.","year":"1989","journal-title":"Invas. 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