{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:47:00Z","timestamp":1752551220409},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":3959,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>De\u2010regulation of c\u2010myc by chromosomal translocation is one crucial step for the development of Burkitt's lymphoma. The de\u2010regulation is caused through juxtaposition of c\u2010myc with one of the 3 immunoglobulin loci. We have reported earlier that treatment of Burkitt's lymphoma cells with n\u2010butyrate causes transcriptional down\u2010regulation of c\u2010myc expression. Because of the possible therapeutic implication of this result, we looked for other compounds which, on the one hand, might be applicable in <jats:italic>vivo<\/jats:italic> and, on the other hand, might cause down\u2010regulation of c\u2010myc expression in Burkitt's lymphoma cells. Since n\u2010butyrate is known to induce differentiation, we have examined other differentiation inducers of different chemical nature for their ability to reduce c\u2010myc expression in Burkitt's lymphoma cells. Many of the substances tested caused down\u2010regulation of c\u2010myc expression, which, however, was transient except for n\u2010butyrate. Three types of compounds proved to be particularly active: polar planar compounds (e.g., dimethylsulfoxide), heterocyclic compounds (e.g., hypoxanthine), and short\u2010chain fatty acids (e.g., n\u2010butyric acid). The action of n\u2010butyrate on c\u2010myc supression was exceptional not only in not being transient, but also in being allele\u2010specific: it down\u2010regulated the translocated allele without affecting the normal one. Medium transfer experiments revealed that neither degradation of the active compound nor an intracellular resistance mechanism can fully account for the reversibility of c\u2010myc down\u2010regulation after treatment with the transiently acting polar planar compounds. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620609","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:45:37Z","timestamp":1171932337000},"page":"697-702","source":"Crossref","is-referenced-by-count":9,"title":["Among 17 inducers of differentiation only sodium butyrate causes a permanent down\u2010regulation of <i>c\u2010myc<\/i> in Burkitt's lymphoma"],"prefix":"10.1002","volume":"62","author":[{"given":"Christoph","family":"Rottleb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Polack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.4990"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(94)90098-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2936"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/287160a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03602.x"},{"key":"e_1_2_1_8_1","first-page":"397","article-title":"The block of elongation in c\u2010myc exon 1 is abolished in Burkitt's\u2010lymphoma cell lines with variant translocation","volume":"3","author":"Eick D.","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_1_9_1","first-page":"265","volume-title":"Psychopharmacology\u2014the third generation of progress","author":"Enna J. 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