{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:57:44Z","timestamp":1775267864645,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3958,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of MAb E\u20109 raised against tissue\u2010cultured endothelial cells (EC) has shown marked heterogeneity in vascular EC lining the blood vessels of normal and tumour tissues. MAb E\u20109 is human EC\u2010specific and the protein recognized by it is a homodimer with a molecular mass of 97 kDa. The E\u20109 protein is resistant to treatment by 3 mM sodium periodate, but is sensitive to 10% trichloroacetic acid and 70% ethanol. E\u20109 protein has been assigned to a new cluster, CD 105, and mapped to human chromosome 9q3. It has approximately 70% homology with type\u2010III cell\u2010surface receptor for transforming growth factor beta (TGF\u2010\u03b2). Recently CD 105 has been reported to be the gene in patients with hereditary haemorrhagic telangiecta\u2010sia. We have examined the effects of radiation on its expression in normal human umbilical\u2010vein endothelial cells (HUVEC) and brain\u2010tumour\u2010derived endothelial cells (BTEC). Irradiation induced dose\u2010and time\u2010dependent up\u2010regulation in the expression of the E\u20109 protein on the plasma membranes of EC, and also resulted in greater increase in the expression of the E\u20109 protein in semi\u2010confluent (proliferating) as compared with confluent (non\u2010proliferating) EC. It may well be that, following radio\u2010therapy in cancer patients, E\u20109 protein is also up\u2010regulated. The presence of increased amounts of E\u20109 protein in EC makes it an attractive target in the control of angiogenesis, especially after radiotherapy in cancer patients. The time scale involved in the up\u2010regulation of E\u20109 protein following irradiation has led us to suggest that it may be a secondary event, the primary being the production and release of mitogenic factors (such as basic fibroblast growth factor) from irradiated EC. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620624","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:45:37Z","timestamp":1171932337000},"page":"791-796","source":"Crossref","is-referenced-by-count":33,"title":["Irradiation induces Up\u2010regulation of E9 protein (CD105) in human vascular endothelial cells"],"prefix":"10.1002","volume":"62","author":[{"given":"Ji\u2010Min","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Van Agthoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin D.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.1.29"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90026-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357908909039849"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311907"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-66-783-181"},{"key":"e_1_2_1_7_1","first-page":"297","article-title":"Vascular lesions following radiation","volume":"23","author":"Fajardo L. 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(In press).","DOI":"10.1002\/(SICI)1096-9896(199604)178:4<363::AID-PATH491>3.0.CO;2-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.2.143"},{"key":"e_1_2_1_17_1","first-page":"1756","volume-title":"Leucocyte differentiation, V","author":"Letarte M.","year":"1995"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656739209038002"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199111000-00003"},{"key":"e_1_2_1_21_1","first-page":"407","article-title":"Endothelial\u2010cell proliferation is induced by radiation in cultured explant of human urothelium and oesophageal mucosa","volume":"61","author":"Mothersill C.","year":"1992","journal-title":"EXS"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7536345"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90148-1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-195-43137"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199309029129"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V64.2.567.567","article-title":"Irradiation induces release of von Willebrand protein from endothelial cells in culture","volume":"64","author":"Sporn L. 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