{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T16:42:02Z","timestamp":1698338522394},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":3935,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA\u2010A2\u2010positive nasopharyngeal carcinoma (<jats:bold>NPC;<\/jats:bold> n = 38) and normal control (n = 51) populations were analysed by high\u2010resolution oligotyping to identify A2 allelic microvariants. Within the control group, A*0207 was found to be the most common allele, accounting for 50% of the A2 frequency in normals. In contrast, this allele was found to be present in only 23% of <jats:bold>NPC<\/jats:bold> cases, suggesting a protective effect. Of these 9 <jats:bold>NPC<\/jats:bold> patients with A*0207, all were associated with B46, unlike in the control group, where it can be found associated with non\u2010B46 antigens. Another allele, A*0201, which was thought to be protective against <jats:bold>NPC<\/jats:bold> was in fact present in 39.5% of <jats:bold>NPC<\/jats:bold> patients, more than twice the frequency in controls. These data confirm that A*0201 is not a protective allele for NPC, and other factors such as the A*0207, non\u2010B46 haplotype are of greater importance.<\/jats:p>","DOI":"10.1002\/ijc.2910630211","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:14:49Z","timestamp":1171934089000},"page":"213-215","source":"Crossref","is-referenced-by-count":6,"title":["HLA\u2010A2 allelic microvariants in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"63","author":[{"given":"E. C.","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace C. T.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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