{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:24:55Z","timestamp":1790133895490,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3934,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effects of bombesin\/GRP antagonists RC\u20103095 and RC\u20103940\u2010II on the growth of SW\u20101990 human pancreatic adenocarcinoma cells xenografted into nude mice or cultured in vitro. Nude mice implanted with SW\u20101990 tumors received s.c. injections of RC\u20103095 and RC\u20103940\u2010II or the vehicle (control) for 28 days. Chronic administration of RC\u20103940\u2010II inhibited the growth of SW\u20101990 tumors, as shown by a reduction in tumor volume during the treatment and a significant increase in tumor doubling time. RC\u20103940\u2010II decreased final tumor volume by 57.7% and tumor growth rate by 65%. Final tumor weights in mice treated with RC\u20103940\u2010II were 75% lower than in controls. Treatment with RC\u20103095 induced smaller, and not significant, decreases in tumor volume and weight. In cell cultures, both RC\u20103095 and RC\u20103940\u2010II effectively inhibited the proliferation of SW\u20101990 cells, inducing a dose\u2010 and time\u2010dependent decrease in the number of cells. RC\u20103940\u2010II again suppressed in vitro growth of SW\u20101990 cells more effectively than RC\u20103095. After 72 hr of culture, RC\u20103940\u2010II and RC\u20103095 at I \u03bcM concentrations decreased cell numbers by 45.7% and 27.7%, respectively. The estimated EC<jats:sub>50<\/jats:sub> value for RC\u20103940\u2010II was I nM. When SW\u20101990 cells were cultured in the presence of I nM and 10 nM RC\u20103095 for 72 hr, cAMP levels in the incubation medium were decreased to 77.3% and 26.9% of the control value. Our results indicate that bombesin\/GRP antagonist RC\u20103940\u2010II can inhibit the proliferation of SW\u20101990 human pancreatic adenocarcinoma cells <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Our findings also suggest that this effect may involve the intracellular cAMP pathway.<\/jats:p>","DOI":"10.1002\/ijc.2910630219","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:14:49Z","timestamp":1171934089000},"page":"257-262","source":"Crossref","is-referenced-by-count":31,"title":["Antagonists of bombesin\/gastrin\u2010releasing peptide inhibit growth of SW\u20101990 human pancreatic adenocarcinoma and production of cyclic AMP"],"prefix":"10.1002","volume":"63","author":[{"given":"Yunfeng","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Zhi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit E.","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Schally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"235","article-title":"Gastrin\u2010releasing peptide receptor\u2010induced internalization, down\u2010regulation, desensitization and growth: possible role for cyclic AMP","volume":"46","author":"Benya R. 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