{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:39:53Z","timestamp":1789940393049,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3897,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hhdman\u2010T\u2010cell\u2010leukemia virus type I (HTLV\u2010I) is the causative agent of adult T\u2010cell leukemia\/lymphomhd (ATL) and tropical spastic paraparesis\/HTLV\u2010I\u2010associated myelopathy (TSP\/HAM). The different disease outcome may be attributable to subtle mutations leading to modification of viral tropism or infectivity. Initial attempts found a very high level of sequence conservation among all HTLV\u2010I strains. However, only one complete proviral DNA sequence is reported from a TSP\/HAM patient, with a provirus derived from immortalized lymphocytes, which might be expected to be a leukemogenic variant rather than a neutrotropic one. We cloned and sequenced a complete HTLV\u2010I provirus (HTLV\u2010I<jats:sub>boi<\/jats:sub>) derived from the uncultured lymphocytes of a sub\u2010acute post\u2010transfusional TSP\/HAM patient with clonal integration of HTLV\u2010I. HTLV\u2010I<jats:sub>boi<\/jats:sub> proviral genome is 9033 bp long, and its overall genetic organization is similar to that of the prototype HTLV\u2010I(ATK), without major deletions or insertions. No premature termination codon was found in the 4 open reading frames of the pX region. Divergence at the nucleotide level of HTLV\u2010l<jats:sub>Boi<\/jats:sub> from the reported full\u2010length HTLV\u2010I varies from 1 to 9.4%, and indicates that it corresponds to a cosmopolitan genotype. This study did not identify specific sequences associated with neurotropic strains.<\/jats:p>","DOI":"10.1002\/ijc.2910630406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:11:41Z","timestamp":1171933901000},"page":"494-499","source":"Crossref","is-referenced-by-count":26,"title":["Human T\u2010cell\u2010leukemia virus type I in post\u2010transfusional spastic paraparesis: Complete proviral sequence from uncultured blood cells"],"prefix":"10.1002","volume":"63","author":[{"given":"Ali","family":"Bazarbachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menger","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gessain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortuna","family":"Saal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Saib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Peries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"De The","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Galibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910600522"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8818"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0882-4010(90)90052-R"},{"key":"e_1_2_1_5_1","first-page":"901","article-title":"Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolates","volume":"58","author":"Fenyo E.","year":"1988","journal-title":"Cell"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1128\/jvi.67.2.1015-1023.1993","article-title":"Complete nucleotide sequence of a highly divergent human\u2010T\u2010cell\u2010leukemia(lymphotropic)\u2010virus\u2010type\u2010I(HTLV\u2010I) variant from Melanesia: genetic and phylogenetic relationship to HTLV\u2010I strains from other geographical regions","volume":"67","author":"Gessain A.","year":"1993","journal-title":"J Virol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/jvi.66.4.2288-2295.1992","article-title":"Low degree of human\u2010T\u2010cell\u2010leukemia\/lymphoma\u2010virus\u2010type\u2010I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations","volume":"66","author":"Gessain A.","year":"1992","journal-title":"J Virol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220607"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304223281608"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3653"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/348245a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8813"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.4049\/jimmunol.143.6.2024","article-title":"Immunodominant sites of human T\u2010cell\u2010lymphotropic\u2010virus\u2010type\u2010I envelope protein for murine helper T cells","volume":"143","author":"Kurata A.","year":"1989","journal-title":"J Immunol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1128\/jvi.65.4.1870-1876.1991","article-title":"Characterization of immunodominant epitopes of gag and pol\u2010gene\u2010encoded proteins of human T\u2010cell lymphotropic virus type I","volume":"65","author":"Lal R.","year":"1991","journal-title":"J. Virol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","unstructured":"Mahieux R. De Th\u00e9 G.andGessain A. The nucleotideTaxmutation at position 7959 of HTLV\u2010I is not associated with tropical\u2010spastic\u2010paraparesis\/HTLV\u2010I associated myelopathy but is linked to the cosmopolitan molecular genotypeJ. Virol.(1995). (In press).","DOI":"10.1128\/jvi.69.9.5925-5927.1995"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-7-1695"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90654-T"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3896"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1991.7.923"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1128\/jvi.69.4.2611-2616.1995","article-title":"Tax mutation associated with tropical\u2010spastic\u2010paraparesis\/human\u2010T\u2010cell\u2010leukemia\u2010virus\u2010type\u2010I\u2010associated myelopathy","volume":"69","author":"Renjifo B.","year":"1995","journal-title":"J Virol."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1128\/jvi.62.1.357-360.1988","article-title":"Identification of point mutations in the envelope gene of Moloney\u2010murine\u2010leukemia\u2010virus TB temperature\u2010sensitive paralytogenic mutant tsl: molecular determinants for neurovirulence","volume":"62","author":"Szurek P.","year":"1988","journal-title":"J. Virol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4049\/jimmunol.147.1.354","article-title":"Identification of a neutralization epitope on the envelope gp46 antigen of human\u2010T\u2010cell\u2010leukemia virus type I and induction of neutralizing antibody by peptide immunization","volume":"147","author":"Tanaka Y.","year":"1991","journal-title":"J. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910630406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910630406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:48:37Z","timestamp":1698288517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910630406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11,15]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,11,15]]}},"alternative-id":["10.1002\/ijc.2910630406"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910630406","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11,15]]}}}