{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:12:50Z","timestamp":1789751570109,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3897,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thde human genes <jats:italic>MAGE<\/jats:italic>\u20101 and \u20103 encode melanoma peptide antigens that are recognized bhd autologous cytotoxic T lymphocytes. Tumors expressing <jats:italic>MAGE<\/jats:italic> genes are potential targets for cancer immunotherapy, because <jats:italic>MAGE<\/jats:italic> genes are expressed only in tumor tissue and not in any normal tissue except testis and placenta. However, little is known about <jats:italic>MAGE<\/jats:italic> gene expression in human esophageal carcinoma. The purpose of this study was therefore to analyze MAGE gene status in human esophageal carcinoma. We studied the expression status of these genes in 42 surgical samples and in 12 cell lines of human esophageal carcinoma using the reverse transcription polymerase chain reaction (RT\u2010PCR). Various clinicopathological factors were also analyzed. No <jats:italic>MAGE<\/jats:italic> gene expression was seen in any of the 42 normal esophageal tissue specimens. In contrast, tumor tissue expressed <jats:italic>MAGE<\/jats:italic>\u20101, \u20102, and \u20103 in 26, 18 and 24 specimens, respectively. Thirty\u2010three of 42 tumors expressed at least one <jats:italic>MAGE<\/jats:italic> gene. Significant clinicopathologic differences between the tumors were not observed, regardless of the presence or absence of <jats:italic>MAGE<\/jats:italic> gene expression. In cell lines, <jats:italic>MAGE<\/jats:italic>\u20101, \u20102, and \u20103 gene expression was recognized in 5, 4 and 4 cell lines, respectively. This study demonstrates that <jats:italic>MAGE<\/jats:italic> genes are frequently expressed in clinical samples as well as in cell lines of esophageal carcinoma. The identification of <jats:italic>MAGE<\/jats:italic> genes, therefore, may open up a new modality of treatment, namely specific immunotherapy, for patients with esophageal carcinoma.<\/jats:p>","DOI":"10.1002\/ijc.2910630411","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:11:41Z","timestamp":1171933901000},"page":"523-526","source":"Crossref","is-referenced-by-count":40,"title":["Human esophageal carcinomas frequently express the tumor\u2010rejection antigens of <i>MAGE<\/i> genes"],"prefix":"10.1002","volume":"63","author":[{"given":"Hiroshi","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Mimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010Ichi","family":"Mafune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Akiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520528"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.489"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.35"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199308000-00004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188615"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90101-R"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.3.921"},{"key":"e_1_2_1_10_1","first-page":"40","volume-title":"TNM classification of malignant tumors","author":"Hermanek P.","year":"1987"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910640115"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468889"},{"key":"e_1_2_1_13_1","first-page":"159","article-title":"Chemotherapy of esophageal cancer","volume":"11","author":"Kalsen D.","year":"1984","journal-title":"Semin. 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