{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:00:59Z","timestamp":1770480059217,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3871,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Research Council of Canada and the National Cancer Institute of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In previous work, we reported the development of the B9\/BM1 syngeneic murine bone marrow metastasis model. Interleukin (IL)\u20106\u2013dependent, IL\u20101\u2013producing B9\/BM1 cells, which preferentially home to and colonise the vertebral and femoral marrow after i.v. injection, exhibit striking similarity in cell surface phenotype to human myeloma cells, especially the expression of 3 adhesion molecules, CD44, VLA\u20104 and ICAM\u2010I. Because the haematopoietic microenvironment consists of different cell types, such as endothelial cells, fibroblasts, adipo\u2010cytes and macrophages, we investigated the functional significance of these adhesion molecules in heterotypic binding assays between B9\/BM1 cells and a newly established bone marrow\u2010derived endothelial cell line (BMEC), a fibroblastoid pre\u2010adipocyte cell line (BMS2.2) and primary bone marrow\u2010derived macrophages. B9\/BM1 cells adhered well to all stromal elements: a combination of monoclonal antibodies (MAbs) against CD44 and VLA\u20104 significantly inhibited the adherence of B9\/ BM1 cells to BMEC and BMS2.2 cells, whereas binding of B9\/BM1 cells to macrophages was partially blocked with an anti\u2010ICAM\u2010I MAb. Our results implicate multiple recognition mechanisms, including those involving CD44, VLA\u20104 and ICAM\u2010I, in the retention of B9\/BM1 cells in the bone marrow. \u00a9 1995 <jats:italic>Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910630613","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:11:25Z","timestamp":1171933885000},"page":"823-830","source":"Crossref","is-referenced-by-count":33,"title":["Adhesion molecules involved in the binding of murine myeloma cells to bone marrow stromal elements"],"prefix":"10.1002","volume":"63","author":[{"given":"Tomoko","family":"Okada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90694-A"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.9.2326.2326"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.380.380"},{"key":"e_1_2_1_5_1","first-page":"1079","article-title":"Metastatic properties conferred on nonmetastatic tumors by hybridization of spleen B\u2010lymphocytes with plasmacytoma cells","volume":"67","author":"De Baetselier P.","year":"1981","journal-title":"J. not. Cancer Inst."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.2060"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90548-D"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1139"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/1040-8428(91)90018-8"},{"key":"e_1_2_1_10_1","first-page":"4613","article-title":"Rat prostate adenocarcinoma cells disseminate to bone and adhere preferentially to bone marrow\u2010derived endothelial cells","volume":"52","author":"Hao M.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(92)90173-Q"},{"key":"e_1_2_1_12_1","first-page":"476","article-title":"Characterization of endothelial cells in murine long\u2010term marrow culture: implication for hemopoietic regulation","volume":"20","author":"Hasthorpe S.","year":"1992","journal-title":"Exp. Hematoi."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.4.1149"},{"key":"e_1_2_1_14_1","first-page":"1","article-title":"The HOX11 homeobox\u2010containing gene of human leukemia immortalizes murine hematopoietic precursors","volume":"9","author":"Hawley R. G.","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.4.1175"},{"key":"e_1_2_1_16_1","first-page":"136","article-title":"Versatile retroviral vectors for potential use in gene therapy","volume":"1","author":"Hawley R. G.","year":"1994","journal-title":"Gene Ther."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00114979"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199109000296"},{"key":"e_1_2_1_19_1","first-page":"610","article-title":"Anti\u2010CD54 (ICAM\u20101) has antitumor activity in SCID mice with human myeloma cells","volume":"55","author":"Huang Y.\u2010W.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(85)90046-3"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/332083a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.2.564.564"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.6.1646.1646"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08302.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90367-Y"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.7.2269.2269"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199202000-00010"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90637-8"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1253"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.2.477"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.114.3.557"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.599"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4049\/jimmunol.144.2.521","article-title":"A mouse lymphoid endothelial cell line immortalized by simian virus 40 binds lymphocytes and retains functional characteristics of normal endothelial cells","volume":"144","author":"O'Connell K.","year":"1990","journal-title":"J. Immunol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01753837"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113419"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180606"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113927"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04252.x"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90327-M"},{"key":"e_1_2_1_40_1","first-page":"2262","article-title":"Prevention of myeloma cell apoptosis by ectopic bcl\u20102 expression or interleukin\u20106\u2013mediated upreg\u2010ulation of bcl\u2010xL","volume":"55","author":"Schwarze M. M. K.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(94)90100-7"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb04692.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.6.1059.1059"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.9.2306.2306"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309145751"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.9.3864"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.11.11"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910630613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910630613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910630613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910630613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:07:41Z","timestamp":1694045261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910630613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,11]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12,11]]}},"alternative-id":["10.1002\/ijc.2910630613"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910630613","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,11]]}}}