{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T22:34:58Z","timestamp":1725662098530},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3871,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maignant lymphomas, which were usually of T\u2010cell type, were Induced in 10 of 13 (77%) male rabbits (Japanese white, 8\/10; New Zealand white, 2\/3) inoculated i.v. with HTLV\u2010II\u2010transformed simian (<jats:italic>Cynomolgus<\/jats:italic>) leukocyte cell line (Si\u2010IIA) cells. Of 7 rabbits injected with cell\u2010free pellets from Si\u2010IIA cultures, 5 also developed malignant lymphoma (15\u201328 days). Lymphoma development was completely inhibited by inactivation of cell\u2010free pellets from Si\u2010IIA culture with ethyl ether and was almost suppressed by neutralization of the cell\u2010free pellets with anti\u2010Si\u2010IIA sera. Herpesvirus particles were discovered very rarely in Si\u2010IIA cells, in addition to C\u2010type virus particles, by electron microscopy. Si\u2010IIA cells were positive for Epstein\u2010Barr\u2010virus(EBV)\u2010associated nuclear antigen (EBNA) by immunofluo\u2010resconce (IF) test. Antibody response to viral capsid antigen of EBV was also detected in sera from rabbits inoculated with Si\u2010IIA. EBV\u2010encoded RNA\u2010I (EBER\u2010I) was demonstrated in Si\u2010IIA, the tumor tissues and all rabbit tumor cell lines by <jats:italic>in situ<\/jats:italic> hybridization. EBV DNA was also detected in Si\u2010IIA and rabbit lymphoma cell lines by polymerase chain reaction (PCR) and Southern blotting. However, EBV DNA was amplified only by some primers complementary to human EBV sequence (B95\u20138), but not by other primers. Integration of HTLV\u2010II provirus genome could not be detected in Si\u2010IIA\u2010induced rabbit tumor cells. Moreover, no lymphoma was induced by inoculation of HTLV\u2010IIC and MOT (other HTLV\u2010II\u2010producing human cell lines), B95\u20108 (EBV\u2010producing cell line) or TALL\u20101 and peripheral leukocytes from normal <jats:italic>Cynomolgus<\/jats:italic> (controls). Neither Herpesvirus saimiri nor H. ateles (simian oncogenic viruses) were detected in Si\u2010IIA cells by IF test. These data suggest that the high rate of lymphoma induction in rabbits may not be caused by HTLV\u2010II, human EBV (B95\u20138) or well\u2010known simian oncogenic viruses, but by EBV\u2010related herpesvirus derived from Si\u2010IIA cells or HTLV\u2010IIA cells, with which Si\u2010IIA was established. The availability of this animal model promises to clarify the role of EBV in human lymphoma and provides a means of studying prophylactic and therapeutic regimens. \u00a9 1995 <jats:italic>Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910630620","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:11:25Z","timestamp":1171933885000},"page":"872-880","source":"Crossref","is-referenced-by-count":15,"title":["Malignant lymphoma induction in rabbits by intravenous inoculation of Epstein\u2010Barr\u2010virus\u2010related herpesvirus from HTLV\u2010II\u2010transformed cynomolgus leukocyte cell line (Si\u2010IIA)"],"prefix":"10.1002","volume":"63","author":[{"given":"Kazuhiko","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tirtha R.","family":"Koirala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Ino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Nil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaatsu","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.1.209.209"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199203000-00037"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.10.6303-6308.1993"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.6.1532.1532"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4163-5_6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.1990.tb00250.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01229527"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1994.tb02952.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1993.tb02824.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_2_1_14_1","first-page":"1899","volume-title":"Virology","author":"Kieff E.","year":"1990"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.5.1116.1116"},{"key":"e_1_2_1_16_1","first-page":"1921","volume-title":"Virology","author":"Miller G.","year":"1990"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.145.4.948"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02634.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02567.x"},{"key":"e_1_2_1_20_1","first-page":"237","article-title":"A human T\u2010cell line with an abnormal trisomy 2 karyotype established by co\u2010culture of peripheral lymphocytes with an HTLV\u2010II\u2010infected simian leukocyte cell line","volume":"43","author":"Ohara N.","year":"1993","journal-title":"Acta pathol. 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