{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:30:39Z","timestamp":1770478239436,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3923,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>MAGE<\/jats:italic> genes encode certain tumor\u2010associated antigens recognized by cytotoxic T lymphocytes. We investigated the expression of the <jats:italic>MAGE<\/jats:italic>\u20101, \u20102, \u20103, \u20104, \u201041 and \u20106 genes in 88 head\u2010and\u2010neck squamous\u2010cell carcinomas (83 fresh tumor samples and 5 cell lines), using a reverse\u2010transcription\u2010polymerase\u2010chain\u2010reaction assay, followed by dot\u2010blot hybridization with sequence\u2010specific oligonucleotides and\/or restriction\u2010enzyme\u2010pattern analysis. The <jats:italic>MAGE<\/jats:italic>\u20101, \u20102, \u20103, \u20104, \u201041 and \u20106 genes were expressed at the mRNA level in 27, 34, 36, 22, 16 and 35, respectively, of 83 fresh tumor samples. At least one of these genes was expressed in 59 of the 83 samples. Neither non\u2010tumor inflammatory cells nor normal tissues were positive for these genes. The <jats:italic>MAGE<\/jats:italic>\u20101 gene was expressed relatively frequently in SCC of the oropharynx, hypopharynx and maxillary sinus, but at lower rates in SCC of the larynx and of the tongue and oral cavity. <jats:italic>MAGE<\/jats:italic>\u20101 was frequently expressed in poorly differentiated SCC, somewhat less frequently in moderately differentiated SCC, and only infrequently in well\u2010differentiated SCC. The expression levels of the other <jats:italic>MAGE<\/jats:italic> genes also varied with the anatomic site as well as the degree of differentiation. Our results suggest that specific immunotherapy against MAGE gene products may be useful for patients with head\u2010and\u2010neck carcinomas. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910640504","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:14:41Z","timestamp":1171934081000},"page":"304-308","source":"Crossref","is-referenced-by-count":49,"title":["Expression of the <i>MAGE<\/i> gene family in human head\u2010and\u2010neck squamous\u2010cell carcinomas"],"prefix":"10.1002","volume":"64","author":[{"given":"Masao","family":"Eura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Ogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chikamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Dac","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Masuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyogo","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860290079018"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520528"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01246677"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188615"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00200020"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01756133"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.3.921"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.390"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00680-Q"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198903000-00007"},{"key":"e_1_2_1_13_1","first-page":"1381","article-title":"Characterization of human papillomavirus (HPV) infection in papilloma of the head and neck","volume":"97","author":"Nakano K.","year":"1994","journal-title":"J. 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