{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:45:57Z","timestamp":1759599957063},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3862,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiological studies on intracranial tumors have suggested that the observed familial aggregation of a proportion of gliomas may be due to inherited predisposition to their development. In the Li\u2010Fraumeni syndrome (LFS) associated with germ\u2010line mutations of the <jats:italic>p53<\/jats:italic> gene, nervous\u2010system tumors are observed with increased frequency. However, the contribution of germ\u2010line <jats:italic>p53<\/jats:italic> mutation to the incidence of brain tumors has not been investigated. In order to address this point, we have performed 2 independent investigations. First, we have examined an unselected series of brain tumors. Whenever the presence of a <jats:italic>p53<\/jats:italic> mutation in the tumor was observed, the possible germ\u2010line origin of the mutation was investigated. Germ\u2010line <jats:italic>p53<\/jats:italic> mutations were also analyzed in constitutional DNA of patients with gliomas that had been selected for an unusual personal or familial history of cancer. Germ\u2010line <jats:italic>p53<\/jats:italic> mutations were detected in 1 out of 80 unselected cases and in 3 out of 15 selected cases (20%). We conclude that germ\u2010line <jats:italic>p53<\/jats:italic> mutation may contribute to a small fraction of gliomas that develop in the general population. The presence of a personal or familial history of cancer in a patient with glioma should prompt the search for a germ\u2010line <jats:italic>p53<\/jats:italic> mutation. However, the low frequency of <jats:italic>p53<\/jats:italic> germ\u2010line mutation suggests that alterations of this gene may not account for most familial cases of gliomas. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910640606","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:42:41Z","timestamp":1171935761000},"page":"383-387","source":"Crossref","is-referenced-by-count":39,"title":["Incidence of germ\u2010line <i>p53<\/i> mutations in patients with gliomas"],"prefix":"10.1002","volume":"64","author":[{"given":"You\u2010Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Sanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kh\u00ea","family":"Hoang\u2010Xaun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Yves","family":"Delattre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Poisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hamelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860315)57:6<1225::AID-CNCR2820570627>3.0.CO;2-P"},{"key":"e_1_2_1_3_1","first-page":"3234","article-title":"Screening for germ\u2010line TP53 mutations in breast cancer patients","volume":"52","author":"B\u00f8rresen A.\u2010L.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","first-page":"4454","article-title":"Database and software for the analysis of mutations in the human p53 gene","volume":"54","author":"Cariello N. 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