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Although ICAM\u20101 was never observed on benign gastric epithelium, even in the presence of chronic inflammation and a strong leukocyte infiltrate, 38% (26\/69) of the primary tumors expressed this molecule. ICAM\u20101 was restricted to differentiated tumors and correlated with the presence of leukocytes and the absence of vessel invasion. The ICAM\u20101 expression pattern of metastatic lesions reflected that of the primary tumor, suggesting that most tumors retain the non\u2010inducible phenotype seen in normal mucosa while some become cytokine\u2010sensitive. ICAM\u20101 expression showed no correlation with tumor relapse or survival. LFA\u20103 was absent from 8% (4\/49) of the primary tumors and reduced (e.g., \u00b1 50% positive cells) in 33% (16\/49). Expression of LFA\u20103 by more than 50% of the tumor cells correlated with cellular dedifferentiation (G3, G4), histologically detectable vessel invasion, tumor recurrence and decreased survival time. Primary tumors and metastases in draining lymph nodes demonstrated a broad range of LFA\u20103 expression. In contrast, distant metastases (liver and peritoneum) had uniformly high frequencies of LFA\u20103\u2010positive cells, suggesting a selective advantage for these cells in the establishment of distant metastases. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910640611","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:42:41Z","timestamp":1171935761000},"page":"415-423","source":"Crossref","is-referenced-by-count":19,"title":["Expression of leukocyte cell adhesion molecules on gastric carcinomas: Possible involvement of lfa\u20103 expression in the development of distant metastases"],"prefix":"10.1002","volume":"64","author":[{"given":"Barbara","family":"Mayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Babic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl W.","family":"Jauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich W.","family":"Schildberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Funke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3343","article-title":"Differential expression of cell adhesion molecules CD54\/CD11a and CD58\/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells","volume":"53","author":"Altomonte M.","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.4049\/jimmunol.151.12.7224","article-title":"Soluble intercellular adhesion molecule 1 inhibits MHC\u2010restricted specific T cell\/tumor interaction","volume":"151","author":"Becker J. 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