{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:30:48Z","timestamp":1785324648997,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology","award":["2012R1A1A2005302"],"award-info":[{"award-number":["2012R1A1A2005302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Chemotherapy\u2010induced alopecia (CIA) is a highly distressing event for cancer patients, and hence, we here aimed to assess the efficacy of various interventions in the prevention of CIA. We searched PubMed, EMBASE and the Cochrane Library, from June 20, 2013 through August 31, 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any intervention for prevention of CIA compared with that of controls. Two authors extracted data independently on dichotomized outcome in terms of CIA occurrence. Relative risks (RRs) and 95% confidential intervals (CIs) were calculated for efficacy of CIA prevention by using random\u2010effect or fixed\u2010effect models. Out of 691 articles retrieved, a total of eight randomized controlled trials and nine controlled clinical trials involving 1,098 participants (616 interventions and 482 controls), were included in the final analyses. Scalp cooling, scalp compression, a combination of cooling and compression, topical minoxidil and <jats:italic>Panicum miliaceum<\/jats:italic> were used as interventions. The participants were mainly breast cancer patients receiving doxorubicin\u2010 or epirubicin\u2010containing chemotherapy. Scalp cooling, which is the most popular preventive method, significantly reduced the risk of CIA (RR\u2009=\u20090.38, 95% CI\u2009=\u20090.32\u20130.45), whereas topical 2% minoxidil and other interventions did not significantly reduce the risk of CIA. No serious adverse effects associated with scalp cooling were reported. Our results suggest that scalp cooling can prevent CIA in patients receiving chemotherapy. However, the long\u2010term safety of scalp cooling should be confirmed in further studies.<\/jats:p>","DOI":"10.1002\/ijc.29115","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T09:10:55Z","timestamp":1406884255000},"source":"Crossref","is-referenced-by-count":110,"title":["Efficacy of interventions for prevention of chemotherapy\u2010induced alopecia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"136","author":[{"given":"Hyoseung","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Jin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Human\u2010Environmental Interface Biology Medical Research Center Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohsang","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Human\u2010Environmental Interface Biology Medical Research Center Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Kwon","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Family Medicine; Center for Cancer Prevention and Detection; Molecular Epidemiology Branch Research Institute and Hospital, National Cancer Center Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2003.00382.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2001.00272.x"},{"key":"e_1_2_5_4_1","first-page":"562","article-title":"A practitioner's guide to cancer\u2010related alopecia","volume":"25","author":"Dorr VJ","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9105-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0562-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.001"},{"key":"e_1_2_5_8_1","first-page":"49","article-title":"The effectiveness of scalp hypothermia in preventing cyclophosphamide\u2010induced alopecia","volume":"14","author":"Parker R","year":"1987","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0475-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi088"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00012-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365518509155250"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/3470010"},{"key":"e_1_2_5_14_1","first-page":"19","article-title":"The effects of using chemocap on occurrence of chemotherapy\u2010induced alopecia","volume":"10","author":"Kennedy M","year":"1983","journal-title":"Oncol nurs forum"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-197904000-00005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01430.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058986"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90500-9"},{"key":"e_1_2_5_19_1","first-page":"129","article-title":"The use of minoxidil to attempt to prevent alopecia during chemotherapy for gynecologic malignancies","volume":"12","author":"Granai CO","year":"1991","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_20_1","first-page":"5123","article-title":"Protection from chemotherapy\u2010induced alopecia by 1,25\u2010dihydroxyvitamin D3","volume":"52","author":"Jimenez JJ","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199904000-00007"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06608.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01262569"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12182"},{"key":"e_1_2_5_25_1","unstructured":"HigginsJPT GreenS. 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