{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T22:24:12Z","timestamp":1743978252385},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Institute SPORE grant","award":["P50 CA093459"],"award-info":[{"award-number":["P50 CA093459"]}]},{"name":"the Miriam and Jim Mulva Melanoma Research Fund and the Marit Peterson Fund for Melanoma Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:p>Cytokines such as Interleukin (IL)\u221212p70 (\u201cIL\u201012\u201d) and IL\u201023 can influence tumor progression. We tested the hypothesis that blood levels of IL\u201012p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between March 1998 and March 2011. Plasma levels of IL\u201012p40 were determined for 573 patients (discovery), 249 patients (Validation 1) and 244 patients (Validation 2). Per 10\u2010unit change of IL\u201012p40 level was used to investigate associations with melanoma patient outcome among all patients or among patients with early or advanced stage. Among stage I\/II melanoma patients in the pooled data set, after adjustment for sex, age, stage and blood draw time from diagnosis, elevated IL\u201012p40 was associated with melanoma recurrence [hazard ratio (HR)\u2009=\u20091.04 per 10\u2010unit increase in IL\u201012p40, 95% CI 1.02\u20131.06, <jats:italic>p<\/jats:italic>\u2009=\u20098.48 \u00d7 10<jats:sup>\u22125<\/jats:sup>]; Elevated IL\u201012p40 was also associated with a poorer melanoma specific survival (HR\u2009=\u20091.06, 95% CI 1.03\u20131.09, <jats:italic>p<\/jats:italic>\u2009=\u20093.35 \u00d7 10<jats:sup>\u22125<\/jats:sup>) and overall survival (HR\u2009=\u20091.05, 95% CI 1.03\u20131.08, <jats:italic>p<\/jats:italic>\u2009=\u20098.78\u00d710<jats:sup>\u22127<\/jats:sup>) in multivariate analysis. Among stage III\/IV melanoma patients in the pooled data set, no significant association was detected between elevated IL\u201012p40 and overall survival, or with melanoma specific survival, with or without adjustment for the above covariates. Early stage melanoma patients with elevated IL\u201012p40 levels are more likely to develop disease recurrence and have a poorer survival. Further investigation with a larger sample size will be needed to determine the role of IL\u201012p40 in advanced stage melanoma patients.<\/jats:p>","DOI":"10.1002\/ijc.29182","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T06:36:54Z","timestamp":1409899014000},"page":"1874-1880","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between blood <scp>IL<\/scp>\u201012p40 level and melanoma progression"],"prefix":"10.1002","volume":"136","author":[{"given":"Shenying","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun 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D.","family":"Reveille","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston Houston TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawen","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Roland L.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010E","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston TX 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