{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:20:34Z","timestamp":1765887634335,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V103B-022","V103E10-001"],"award-info":[{"award-number":["V103B-022","V103E10-001"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009096","name":"Taiwan Clinical Oncology Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009096","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:p>The relationship between chronic myeloid leukemia (CML) and tuberculosis (TB) has not been determined. We conducted a national survey including 1,082 CML patients identified from the Taiwan National Health Insurance database covering a period between 1998 and 2011; the matched non\u2010exposed cohort included 10,820 subjects without CML that were matched for age, sex and comorbidities. The impact of TB was measured by the overall mortality, and the risk factors were identified by a multivariate Cox proportional hazards model. We found the risk of TB was higher in the CML cohort, with an adjusted hazard ratio (aHR) of 3.76 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) for both pulmonary (aHR 3.23, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and extrapulmonary (aHR 9.77, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) TB. Specific risk factors were: aged\u2009\u2265\u200960 (aHR 3.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.022), being male (aHR 13.49, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), receiving stem cell transplantation (aHR 10.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and interferon\u2010\u03b1 therapy (aHR 3.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.011). CML patients with TB had a higher mortality rate than those without (aHR 2.04, <jats:italic>p<\/jats:italic>\u2009=\u20090.043). We conclude that the incidence of TB is significantly higher in CML patients of male sex, aged\u2009\u2265\u200960, having received either stem cell transplantation or interferon\u2010\u03b1 treatment. Careful screening strategies for TB should be considered for CML patients with high risk of the infection.<\/jats:p>","DOI":"10.1002\/ijc.29201","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T14:47:56Z","timestamp":1410360476000},"page":"1881-1887","source":"Crossref","is-referenced-by-count":17,"title":["Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population\u2010based study in <scp>T<\/scp>aiwan"],"prefix":"10.1002","volume":"136","author":[{"given":"Chia\u2010Jen","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Public Health National Yang\u2010Ming University Taipei 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