{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:08:07Z","timestamp":1762866487143},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"World Cancer Research Fund International (WCRF) and Wereld Kanker Onderzoek Fonds (WCRF NL)","award":["2010\/253"],"award-info":[{"award-number":["2010\/253"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head\u2013neck cancer (HNC) subtypes [<jats:italic>i.e<\/jats:italic>., oral cavity cancer (OCC), oro\u2010\/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852 participants completed a 150\u2010item food frequency questionnaire at baseline in 1986. After 20.3 years of follow\u2010up, 415 cases of HNC (131 OCC, 88 OHPC, three oral cavity\/pharynx unspecified or overlapping and 193 LC) and 3,898 subcohort members were available for case\u2013cohort analysis using Cox proportional hazards models. Total vegetable and fruit consumption was inversely associated with risk of HNC overall [multivariable\u2010adjusted rate ratios for highest <jats:italic>vs<\/jats:italic>. lowest quartile: 0.61, 95% confidence interval (CI) 0.44\u20130.85, <jats:italic>p<\/jats:italic> trend 0.002] and all HNC subtypes, with the strongest associations for OCC. Total vegetable intake and total fruit intake were also associated with a decreased risk of HNC overall and HNC subtypes. No significant interaction was found between vegetable and fruit intake and alcohol consumption or cigarette smoking. In conclusion, in this large\u2010scale cohort study, consumption of vegetables and fruits was associated with a decreased risk of HNC overall and all subtypes. Consumption of vegetables and fruits (or of specific groups of them) may protect against HNC and its subtypes.<\/jats:p>","DOI":"10.1002\/ijc.29219","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T11:05:22Z","timestamp":1410779122000},"source":"Crossref","is-referenced-by-count":30,"title":["Consumption of vegetables and fruits and risk of subtypes of head\u2013neck cancer in the <scp>N<\/scp>etherlands <scp>C<\/scp>ohort <scp>S<\/scp>tudy"],"prefix":"10.1002","volume":"136","author":[{"given":"Denise H.E.","family":"Maasland","sequence":"first","affiliation":[{"name":"Department of Epidemiology GROW \u2010 School for Oncology &amp; Developmental Biology, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet A.","family":"van den Brandt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology GROW \u2010 School for Oncology &amp; Developmental Biology, Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery GROW \u2010 School for Oncology &amp; Developmental Biology, Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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