{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:54:47Z","timestamp":1791140087364,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"B\u00f8rnecancerfonden (The Danish Childhood Cancer Foundation)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:p>Large population\u2010based studies are needed to examine the effect of maternal use of fertility drugs on the risk of cancer in children, while taking into account the effect of the underlying infertility. A cohort of 123,322 children born in Denmark between 1964 and 2006 to 68,255 women who had been evaluated for infertility was established. We used a case\u2013cohort design and calculated hazard ratios (HRs) for cancer in childhood (0\u201319 years) and in young adulthood (20\u201329 years) associated with maternal use of six groups of fertility drugs (clomiphene, gonadotropins [<jats:italic>i.e<\/jats:italic>., human menopausal gonadotropins and follicle\u2010stimulating hormone], gonadotropin\u2010releasing hormone analogs, human chorionic gonadotropins, progesterone and other fertility drugs). We found no statistically significant association between maternal use of fertility drugs and risk for overall cancer in childhood or young adulthood. However, with regard to specific cancers in childhood, our results showed that maternal use of progesterone before childbirth markedly increased the risks of their offspring for acute lymphocytic leukemia (any use: HR, 4.95; 95% CI, 1.69\u201314.54;\u2009\u2265\u2009three cycles of use: HR, 9.96; 95% CI, 2.63\u201337.77) and for sympathetic nervous system tumors (any use: HR, 5.79; 95% CI, 1.23\u201327.24;\u2009\u2265\u2009three cycles of use: HR, 8.51; 95% CI, 1.72\u201342.19). These findings show that maternal use of progesterone may increase the risk for specific cancers in the offspring. Additional large epidemiological studies are urgently needed to confirm our finding.<\/jats:p>","DOI":"10.1002\/ijc.29235","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T13:32:36Z","timestamp":1411651956000},"page":"1931-1939","source":"Crossref","is-referenced-by-count":37,"title":["Maternal use of fertility drugs and risk of cancer in children\u2014A nationwide population\u2010based cohort study in <scp>D<\/scp>enmark"],"prefix":"10.1002","volume":"136","author":[{"given":"Marie","family":"Hargreave","sequence":"first","affiliation":[{"name":"Unit of Virus Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor Sch\u00fctt Svane","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie Palmgren","family":"Colov","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Kaae","family":"Andersen","sequence":"additional","affiliation":[{"name":"Unit of Statistics, Bioinformatics and Registry Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne Kr\u00fcger","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Unit of Virus Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"},{"name":"Department of Obstetrics and Gynecology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.06.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.02.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-S1-S8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17550-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.12.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008682"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det278"},{"key":"e_1_2_7_9_1","unstructured":"Danish Fertility Society. 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