{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:36:48Z","timestamp":1784569008921,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"crossref","award":["CA-103-SP-01, MOHW103-TD-B-111-06"],"award-info":[{"award-number":["CA-103-SP-01, MOHW103-TD-B-111-06"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:p>Recent studies suggested that human papillomavirus (HPV) is an emerging risk factor of head and neck cancer (HNC), particularly for oropharyngeal cancer. Studies from the West showed a rising trend of HPV\u2010related HNC despite a decrease of the overall HNC incidence. In contrast, the overall HNC incidence in Taiwan has continued to rise. It is not clear whether the incidence trends of HPV\u2010related HNC in Taiwan have a similar pattern to those from countries with an overall decreasing incidence of HNC. This study examined the incidence trends of HPV\u2010related and HPV\u2010unrelated HNC in Taiwan using data from the Taiwan Cancer Registry. Our results showed that the incidence trends of HPV\u2010related and HPV\u2010unrelated HNC in Taiwan both rose during 1995\u20132009. The incidence of HPV\u2010related HNC (1.3 per 100,000 in 1995 to 3.3 in 2009, annual percentage change (APC)\u2009=\u20096.9, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) rose more rapidly than the incidence of HPV\u2010unrelated HNC (10.4 per 100,000 in 1995 to 21.7 in 2009, APC\u2009=\u20095.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The rising trend of HPV\u2010related HNC was particularly prominent for HNC occurring in tonsil (APC\u2009=\u20098.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), in men (APC\u2009=\u20097.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and in those aged between 40 and 50 years (APC\u2009=\u20098.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Although the overall incidence of HNC in Taiwan has continued to increase, the most rapid rise is in the HPV\u2010related HNC. This suggests that similar to the Western world, HPV\u2010related HNC is becoming an important public health issue in Taiwan.<\/jats:p>","DOI":"10.1002\/ijc.29330","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T10:04:58Z","timestamp":1415959498000},"page":"395-408","source":"Crossref","is-referenced-by-count":81,"title":["Incidence trends of human papillomavirus\u2010related head and neck cancer in Taiwan, 1995\u20132009"],"prefix":"10.1002","volume":"137","author":[{"given":"Tzer\u2010Zen","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology E\u2010DA Hospital and I\u2010Shou University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenn\u2010Ren","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Rung","family":"Tsai","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research, National Health Research Institutes Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Chang","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research, National Health Research Institutes Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al. 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