{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:04:29Z","timestamp":1792188269026,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["442960"],"award-info":[{"award-number":["442960"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["552429"],"award-info":[{"award-number":["552429"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT0990987"],"award-info":[{"award-number":["FT0990987"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of France, the French ARC Foundation for Cancer Research and the Rene Touraine Foundation","award":["PIOF-GA-2011"],"award-info":[{"award-number":["PIOF-GA-2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"<jats:p>Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the \u201cchronic sun exposure\u201d and \u201cnevus\u201d pathways. While chronic sun exposure probably causes many head\/neck melanomas, its role at other sites is unclear. In a population\u2010based, case\u2010case comparison study conducted in Brisbane, Australia, we determined the prevalence and epidemiologic correlates of chronic solar damage in skin adjacent to invasive, incident melanomas on the trunk (<jats:italic>n<\/jats:italic>\u2009=\u2009418) or head\/neck (<jats:italic>n<\/jats:italic>\u2009=\u200992) among patients aged 18\u201379 in 2007\u20132010. Participants self\u2010reported information about environmental and phenotypic factors, and a dermatologist counted nevi and actinic keratoses. Dermatopathologists assessed solar elastosis adjacent to each melanoma using a four\u2010point scale (nil, mild, moderate, marked), and noted the presence or absence of adjacent neval remnants. We measured associations between various factors and solar elastosis using polytomous logistic regression. Marked or moderate solar elastosis was observed in 10% and 27%, respectively, of trunk melanomas, and 60% and 17%, respectively, of head\/neck melanomas. At both sites, marked elastosis was positively associated with age (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.0001) and inversely associated with neval remnants (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.001). For trunk melanomas, marked elastosis was associated with highest quartiles of total sun exposure [odds\u2010ratio (OR)\u2009=\u20095.47, 95% confidence interval (CI)\u2009=\u20091.08\u201327.60] and facial freckling (OR\u2009=\u20092.98, 95% CI\u2009=\u20091.17\u20137.56), and inversely associated with deeply tanning skin (OR\u2009=\u20090.29, 95% CI\u2009=\u20090.08\u20131.11) and high nevus counts (OR\u2009=\u20090.08, 95% CI\u2009=\u20090.01\u20130.66). Mostly similar associations were observed with moderate solar elastosis. About one in three trunk melanomas in Queensland have evidence of moderate\u2010to\u2010marked sun damage, and they differ in risk associations from those without.<\/jats:p>","DOI":"10.1002\/ijc.29335","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T05:35:50Z","timestamp":1416288950000},"page":"2900-2911","source":"Crossref","is-referenced-by-count":30,"title":["Solar elastosis and cutaneous melanoma: A site\u2010specific analysis"],"prefix":"10.1002","volume":"136","author":[{"given":"Marina","family":"Kvaskoff","sequence":"first","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"},{"name":"Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP), \u201cNutrition, Hormones and Women's Health\u201d Team F\u201094805 Villejuif France"},{"name":"Univ. Paris Sud 11, UMRS 1018 F\u201094807 Villejuif France"},{"name":"Gustave Roussy F\u201094805 Villejuif France"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham &amp; Women's Hospital and Harvard Medical School Boston MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Pandeya","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"},{"name":"School of Population Health, The University of Queensland Herston QLD 4006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le C.","family":"Green","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"},{"name":"Institute of Inflammation and Repair, University of Manchester Manchester Academic Health Sciences Centre Manchester M13 9PL United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Perry","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Baxter","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia B.","family":"Davis","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Mortimore","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Queensland Medical Laboratory Murarrie QLD 4172 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Westacott","sequence":"additional","affiliation":[{"name":"Medical Administration Queensland Health Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Wood","sequence":"additional","affiliation":[{"name":"Anatomical Pathology IQ Pathology West End QLD 4101 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Triscott","sequence":"additional","affiliation":[{"name":"Anatomical Pathology IQ Pathology West End QLD 4101 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Williamson","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Sullivan Nicolaides Pathology Taringa QLD 4068 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute Herston QLD 4006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","volume-title":"Cancer incidence in five continents","author":"IARC","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1957.tb59648.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1988.tb03588.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350403"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971009)73:2<198::AID-IJC6>3.0.CO;2-R"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.3.418"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<276::AID-IJC2>3.0.CO;2-S"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.18"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.806"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008980919928"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70436-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0097"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90294-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0475"},{"key":"e_1_2_7_16_1","volume-title":"Skin Pathology","author":"Strutton G","year":"1997"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.06.014"},{"key":"e_1_2_7_18_1","unstructured":"English DR MacLennan R Rivers J et al. 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