{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:07:55Z","timestamp":1779926875546,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Developing countries are interested in using human papillomavirus (HPV) testing as a primary screening test for cervical cancer prevention programs. The low specificity of the HPV assay requires triage testing of HPV\u2010positive women. The aim of the study is to compare visual inspection with acetic acid (VIA) and cytology as triage testing methods in HPV\u2010positive women to detect cervical intraepithelial neoplasia or Grade 2 or higher (CIN2+). The study was conducted in two Cameroonian towns (Yaound\u00e9 and Edea) and included 846 eligible women aged 25 to 65 years. All participants performed self\u2010HPV testing. HPV\u2010positive women (<jats:italic>n<\/jats:italic> = 259) were randomly assigned to be tested either by VIA (VIA group) or cytology (cytology group). HPV\u2010positive women had both cervical biopsy and endocervical curettage to detect biopsy\u2010confirmed CIN2+. All statistical tests were two\u2010sided. The prevalence of HPV was 38.5%, and the mean age of HPV\u2010positive women was 41.5 \u00b1 10.1 years. One hundred ninety\u2010eight women (97 in the VIA group and 99 in the cytology) were randomly assigned to one of the two testing arms. The sensitivity of VIA was 25.0% (95% CI, 7.1\u201359.1%), and the sensitivity of cytology was 90.0% (59.6\u201398.2%). The specificity was 74.2% (95% CI, 64.2\u201382.1%) for VIA and 85.2% (76.3\u201391.2%) for cytology. ROC area for cytology was 0.910 against the 0.496 area for VIA. In this trial, VIA was inferior to cytology as a triage test among HPV\u2010positive women. Further investigations are needed to determine the optimal triage method for HPV\u2010positive women.<\/jats:p>","DOI":"10.1002\/ijc.29353","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T14:19:20Z","timestamp":1416838760000},"page":"127-134","source":"Crossref","is-referenced-by-count":60,"title":["Cervical cancer screening in sub\u2010<scp>S<\/scp>aharan <scp>A<\/scp>frica: A randomized trial of <scp>VIA<\/scp> versus cytology for triage of <scp>HPV<\/scp>\u2010positive women"],"prefix":"10.1002","volume":"137","author":[{"given":"J\u00e9r\u00f4me","family":"Bigoni","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Gundar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Marie","family":"Tebeu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Centre Hospital Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adamo","family":"Bongoe","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Edea Regional Hospital Edea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Fokom\u2010Domgue","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics University Centre Hospital Yaound\u00e9 Cameroon"},{"name":"Department of Gynecology and Obstetrics Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Catarino","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne Foguem","family":"Tincho","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Edea Regional Hospital Edea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bougel","sequence":"additional","affiliation":[{"name":"Argot Lab SA Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vassilakos","sequence":"additional","affiliation":[{"name":"Geneva Foundation for Medical Education and Research Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Petignat","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Geneva University Hospitals Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60035-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.08.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00623.x"},{"key":"e_1_2_5_5_1","unstructured":"PapillomavirusH.Related Cancers in Cameroon. 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