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During 2002\u20132005, residual liquid\u2010based cervical cytology samples were collected from women screened for cervical cancer in Copenhagen, Denmark. Samples were HPV\u2010tested with Hybrid Capture 2 (HC2) and genotyped with INNO\u2010LiPA. Semi\u2010quantitative viral load was measured by HC2 relative light units in women with single hrHPV infections. The cohort was followed in a nationwide pathology register for up to 11.5 years. In women aged \u226530 years at baseline, the 8\u2010year absolute risk for CIN3+ following baseline detection of HPV16 was 21.8% (95% confidence interval [CI]: 18.0\u201325.6%). The corresponding risks for HPV18, HPV31, HPV33, and other hrHPV types, respectively, were 12.8% (95% CI: 7.6\u201318.0%), 11.3% (95% CI: 7.7\u201314.9%), 12.9% (95% CI: 7.0\u201318.8%) and 3.9% (95% CI: 2.7\u20135.2%). Similar absolute risk estimates were observed in women aged &lt;30 years. Higher HPV16\u2010viral load was associated with increased risk of CIN3+ (hazard ratio\u2009=\u20091.34, 95% CI: 1.10\u20131.64, per 10\u2010fold increase in viral load). A similar trend, although statistically nonsignificant, was found for viral load of HPV18. The 8\u2010year absolute risk of CIN3+ in women with HPV16\u2010viral load \u2265100.0 pg\/ml was 30.2% (95% CI: 21.9\u201338.6%). Our results support that hrHPV genotyping during cervical cancer screening may help identify women at highest risk of CIN3+.<\/jats:p>","DOI":"10.1002\/ijc.29374","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T03:47:06Z","timestamp":1417751226000},"page":"193-203","source":"Crossref","is-referenced-by-count":68,"title":["Long\u2010term risk of cervical intraepithelial neoplasia grade 3 or worse according to high\u2010risk human papillomavirus genotype and semi\u2010quantitative viral load among 33,288 women with normal cervical cytology"],"prefix":"10.1002","volume":"137","author":[{"given":"Louise T.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Unit of Statistics, Bioinformatics and Registry, 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