{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:03:34Z","timestamp":1790777014002,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto Salud Carlos III","award":["PI08\/1770"],"award-info":[{"award-number":["PI08\/1770"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>\n                    Night shift work has been classified as a probable human carcinogen based on experimental studies and limited human evidence on breast cancer. Evidence on other common cancers, such as prostate cancer, is scarce. Chronotype is an individual characteristic that may relate to night work adaptation. We evaluated night shift work with relation to prostate cancer, taking into account chronotype and disease severity in a population based case\u2010control study in Spain. We included 1,095 prostate cancer cases and 1,388 randomly selected population controls. We collected detailed information on shift schedules (permanent\n                    <jats:italic>vs<\/jats:italic>\n                    . rotating, time schedules, duration, frequency), using lifetime occupational history. Sociodemographic and lifestyle factors were assessed by face\u2010to\u2010face interviews and chronotype through a validated questionnaire. We used unconditional logistic regression analysis adjusting for potential confounders. Subjects who had worked at least for one year in night shift work had a slightly higher prostate cancer risk [Odds Ratio (OR) 1.14; 95%CI 0.94, 1.37] compared with never night workers; this risk increased with longer duration of exposure (\u226528 years: OR 1.37; 95%CI 1.05, 1.81;\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend\u2009=\u20090.047). Risks were more pronounced for high risk tumors [D'Amico classification, Relative Risk Ratio (RRR) 1.40; 95%CI 1.05, 1.86], particularly among subjects with longer duration of exposure (\u226528 years: RRR 1.63; 95%CI 1.08, 2.45;\n                    <jats:italic>p<\/jats:italic>\n                    \u2010trend\u2009=\u20090.027). Overall risk was higher among subjects with an evening chronotype, but also increased in morning chronotypes after long\u2010term night work. In this large population based study, we found an association between night shift work and prostate cancer particularly for tumors with worse prognosis.\n                  <\/jats:p>","DOI":"10.1002\/ijc.29400","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T01:49:26Z","timestamp":1419040166000},"page":"1147-1157","source":"Crossref","is-referenced-by-count":153,"title":["Night shift work, chronotype and prostate cancer risk in the MCC\u2010\n                    <scp>S<\/scp>\n                    pain case\u2010control study"],"prefix":"10.1002","volume":"137","author":[{"given":"Kyriaki","family":"Papantoniou","sequence":"first","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"Bioanalysis Research Group IMIM (Hospital Del Mar Medical Research Institute) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda Y Salud P\u00fablica (CIBERESP) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Casta\u00f1o\u2010Vinyals","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"Bioanalysis Research Group IMIM (Hospital Del Mar Medical Research Institute) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda Y Salud P\u00fablica (CIBERESP) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"Bioanalysis Research Group IMIM (Hospital Del Mar Medical Research Institute) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"CIBER Epidemiolog\u00eda Y Salud P\u00fablica (CIBERESP) Madrid 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