{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:10:06Z","timestamp":1789852206238,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":223,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"American University of Beirut Medical Practice Plan and the American University of Beirut University Research Board"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Cancer"],"published-print":{"date-parts":[[2015,8,1]]},"DOI":"10.1002\/ijc.29407","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T18:51:40Z","timestamp":1419879100000},"page":"698-709","source":"Crossref","is-referenced-by-count":22,"title":["ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model"],"prefix":"10.1002","volume":"137","author":[{"given":"Rihab R.","family":"Nasr","sequence":"first","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiological Sciences; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed A.","family":"Hmadi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab M.","family":"El-Eit","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiological Sciences; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad N.","family":"Iskandarani","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiological Sciences; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazi S.","family":"Zaatari","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois-Xavier","family":"Mahon","sequence":"additional","affiliation":[{"name":"Laboratoire D'h\u00e9matologie Et Service Des Maladies Du Sang; CHU De Bordeaux, Universit\u00e9 Victor S\u00e9galen Bordeaux 2, INSERM U876; Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio C.P.","family":"Pisano","sequence":"additional","affiliation":[{"name":"BIOGEM, Medicinal Investigational Research; Ariano Irpino (AV) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine D.","family":"Darwiche","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics; American University of Beirut; Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"10.1002\/ijc.29407-BIB0001|ijc29407-cit-0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/156800911793743619","article-title":"Molecular pathogenesis of Philadelphia-positive chronic myeloid Leukemia-is it all BCR-ABL?","volume":"10","author":"Rumpold","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1002\/ijc.29407-BIB0002|ijc29407-cit-0002","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.leukres.2010.04.016","article-title":"BCR-ABL tyrosine kinase inhibitors in the treatment of philadelphia chromosome positive chronic myeloid leukemia: a review","volume":"10","author":"An","year":"2010","journal-title":"Leuk Res"},{"key":"10.1002\/ijc.29407-BIB0003|ijc29407-cit-0003","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.4161\/cc.8.9.8209","article-title":"The CML stem cell","volume":"9","author":"Stuart","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1002\/ijc.29407-BIB0004|ijc29407-cit-0004","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1182\/blood.V86.6.2371.bloodjournal8662371","article-title":"Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression","volume":"6","author":"Gaiger","year":"1995","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0005|ijc29407-cit-0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1182\/asheducation-2003.1.132","article-title":"Chronic myeloid Leukemia","author":"Melo","year":"2003","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1002\/ijc.29407-BIB0006|ijc29407-cit-0006","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11899-012-0117-2","article-title":"Curing chronic myeloid leukemia","volume":"7","author":"Rea","year":"2012","journal-title":"Curr Hematol Malig"},{"key":"10.1002\/ijc.29407-BIB0007|ijc29407-cit-0007","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.blre.2011.02.001","article-title":"Interpretation of cytogenetic and molecular results in patients treated for CML","volume":"5","author":"Vigil","year":"2011","journal-title":"Blood Rev"},{"key":"10.1002\/ijc.29407-BIB0008|ijc29407-cit-0008","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/asheducation-2011.1.128","article-title":"Educational session: managing chronic myeloid leukemia as a chronic disease","volume":"11","author":"Hochhaus","year":"2011","journal-title":"Hematology"},{"key":"10.1002\/ijc.29407-BIB0009|ijc29407-cit-0009","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1200\/JCO.2012.48.5797","article-title":"Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease","volume":"5","author":"Rousselot","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1002\/ijc.29407-BIB0010|ijc29407-cit-0010","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1158\/1078-0432.CCR-13-1988","article-title":"Deep molecular response in chronic myeloid leukemia: the new goal of therapy?","volume":"2","author":"Mahon","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1002\/ijc.29407-BIB0011|ijc29407-cit-0011","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1158\/1078-0432.CCR-10-2922","article-title":"Second-generation tyrosine kinase inhibitors: the future of frontline CML therapy","volume":"17","author":"Kantarjian","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1002\/ijc.29407-BIB0012|ijc29407-cit-0012","first-page":"424","article-title":"Therapy options in imatinib failures","volume":"4","author":"DiPersio","year":"2008","journal-title":"Oncologist"},{"key":"10.1002\/ijc.29407-BIB0013|ijc29407-cit-0013","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/leu.2010.143","article-title":"Critical molecular pathways in cancer stem cells of chronic myeloid leukemia","volume":"9","author":"Chen","year":"2010","journal-title":"Leukemia"},{"key":"10.1002\/ijc.29407-BIB0014|ijc29407-cit-0014","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s13238-013-2115-0","article-title":"Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells","volume":"3","author":"Zhang","year":"2013","journal-title":"Protein Cell"},{"key":"10.1002\/ijc.29407-BIB0015|ijc29407-cit-0015","doi-asserted-by":"crossref","first-page":"479S","DOI":"10.1093\/jn\/130.2.479S","article-title":"Advances in the development of retinoids as chemopreventive agents","volume":"130","author":"Lippman","year":"2000","journal-title":"J Nutr"},{"key":"10.1002\/ijc.29407-BIB0016|ijc29407-cit-0016","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathol-011110-130303","article-title":"Retinoids, retinoic acid receptors, and cancer","volume":"6","author":"Tang","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1002\/ijc.29407-BIB0017|ijc29407-cit-0017","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2141.1995.tb05147.x","article-title":"All trans-retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD4+ haemopoietic progenitor cells","volume":"90","author":"Zauli","year":"1995","journal-title":"Br J Hematol"},{"key":"10.1002\/ijc.29407-BIB0018|ijc29407-cit-0018","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1096\/fasebj.10.9.8801177","article-title":"Altered retinoic acid receptors","volume":"9","author":"The","year":"1996","journal-title":"FASEB"},{"key":"10.1002\/ijc.29407-BIB0019|ijc29407-cit-0019","first-page":"4942","article-title":"Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the rasHa oncogene and high risk for premalignant progression","volume":"56","author":"Darwiche","year":"1996","journal-title":"Cancer Res"},{"key":"10.1002\/ijc.29407-BIB0020|ijc29407-cit-0020","first-page":"89892","article-title":"All-trans retinoic acid esters and amides","volume":"88","author":"Gander","year":"1978","journal-title":"Chem Abstr"},{"key":"10.1002\/ijc.29407-BIB0021|ijc29407-cit-0021","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jm025593y","article-title":"A novel atypical retinoid endowed with proapoptotic and antitumor activity","volume":"46","author":"Cincinelli","year":"2003","journal-title":"J Med Chem"},{"key":"10.1002\/ijc.29407-BIB0022|ijc29407-cit-0022","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1182\/blood-2003-05-1577","article-title":"ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis","volume":"103","author":"Garattini","year":"2004","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0023|ijc29407-cit-0023","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/annonc\/mdm195","article-title":"Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models","volume":"9","author":"Pisano","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1002\/ijc.29407-BIB0024|ijc29407-cit-0024","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/ijc.24819","article-title":"Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response","volume":"5","author":"Zuco","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.29407-BIB0025|ijc29407-cit-0025","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1182\/blood-2014-03-560060","article-title":"Pre-clinical efficacy of the synthetic retinoid ST1926 for treating adult T cell leukemia\/lymphoma","volume":"124","author":"El Hajj","year":"2014","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0026|ijc29407-cit-0026","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1158\/1535-7163.MCT-08-0419","article-title":"Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity","volume":"9","author":"Valli","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1002\/ijc.29407-BIB0027|ijc29407-cit-0027","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1179\/joc.2004.16.Supplement-1.74","article-title":"Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926","volume":"4","author":"Pisano","year":"2004","journal-title":"J Chemother"},{"key":"10.1002\/ijc.29407-BIB0028|ijc29407-cit-0028","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1124\/mol.106.023614","article-title":"Antitumor activity of the retinoid-related molecules (E)-3-(4\u2032hydroxy-3\u2032- adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl] -2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: role of retinoic acid receptor gamma and retinoid-independent pathways","volume":"3","author":"Parrella","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1002\/ijc.29407-BIB0029|ijc29407-cit-0029","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.ejca.2012.11.013","article-title":"New insights into the molecular mechanisms underlying sensitivity\/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase a and the proteasome","volume":"6","author":"Fratelli","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1002\/ijc.29407-BIB0030|ijc29407-cit-0030","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bcp.2006.10.033","article-title":"The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism","volume":"5","author":"Francesco","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/ijc.29407-BIB0031|ijc29407-cit-0031","first-page":"993","article-title":"Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence in adult T-cell leukemia\/lymphoma and apoptosis in peripheral T-cell lymphomas","volume":"4","author":"Darwiche","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.29407-BIB0032|ijc29407-cit-0032","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/ijc.28427","article-title":"Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha","volume":"4","author":"El Eit","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1002\/ijc.29407-BIB0033|ijc29407-cit-0033","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1158\/1078-0432.CCR-0957-03","article-title":"Imatinib mesylate efficiently achieves therapeutic intratumor concentrations in vivo but has limited activity in a xenograft model of small cell lung cancer","volume":"10","author":"Wolff","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1002\/ijc.29407-BIB0034|ijc29407-cit-0034","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1200\/JCO.1993.11.10.2036","article-title":"Five-year administration of fenretinide: pharmacokinetics and effects on plasma retinol concentrations","volume":"11","author":"Formelli","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1002\/ijc.29407-BIB0035|ijc29407-cit-0035","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1593\/neo.05127","article-title":"Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response","volume":"7","author":"Zuco","year":"2005","journal-title":"Neoplasia"},{"key":"10.1002\/ijc.29407-BIB0036|ijc29407-cit-0036","doi-asserted-by":"crossref","first-page":"212","DOI":"10.18632\/aging.100019","article-title":"Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells","volume":"2","author":"Nakamura","year":"2009","journal-title":"Aging"},{"key":"10.1002\/ijc.29407-BIB0037|ijc29407-cit-0037","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/blood.V92.10.3780","article-title":"Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr\/abl-transduced bone marrow","volume":"92","author":"Pear","year":"1998","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0038|ijc29407-cit-0038","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1182\/blood-2011-01-330621","article-title":"Kill one bird with two stones: potential efficacy of BCRABL and autophagy inhibition in CML","volume":"118","author":"Helgason","year":"2011","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0039|ijc29407-cit-0039","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1038\/sj.onc.1204779","article-title":"Crk family adaptors-signalling complex formation and biological roles","volume":"44","author":"Feller","year":"2001","journal-title":"Oncogene"},{"key":"10.1002\/ijc.29407-BIB0040|ijc29407-cit-0040","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/jcb.24749","article-title":"Crk at the quarter century mark: perspectives in signaling and cancer","volume":"5","author":"Kumar","year":"2014","journal-title":"J Cell Biochem"},{"key":"10.1002\/ijc.29407-BIB0041|ijc29407-cit-0041","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ccr.2008.11.001","article-title":"Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis","volume":"6","author":"Shah","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1002\/ijc.29407-BIB0042|ijc29407-cit-0042","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1158\/1535-7163.MCT-11-1040","article-title":"DNA damage repair pathways in cancer stem cells","volume":"8","author":"Maugeri-Sacc\u00e0","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"10.1002\/ijc.29407-BIB0043|ijc29407-cit-0043","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","article-title":"Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro","volume":"99","author":"Graham","year":"2002","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0044|ijc29407-cit-0044","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1182\/blood-2010-12-326843","article-title":"Chronic myeloid leukemia stem cells are not dependent on Bcr-abl kinase activity for their survival","volume":"119","author":"Hamilton","year":"2012","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0045|ijc29407-cit-0045","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.leukres.2010.11.004","article-title":"The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study)","volume":"6","author":"Deau","year":"2011","journal-title":"Leuk Res"},{"key":"10.1002\/ijc.29407-BIB0046|ijc29407-cit-0046","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1158\/1078-0432.CCR-12-2455","article-title":"Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an institute of medicine workshop","volume":"22","author":"LoRusso","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1002\/ijc.29407-BIB0047|ijc29407-cit-0047","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/blood-2009-06-228130","article-title":"PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice","volume":"3","author":"Peng","year":"2010","journal-title":"Blood"},{"key":"10.1002\/ijc.29407-BIB0048|ijc29407-cit-0048","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ng.2350","article-title":"The blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells","volume":"8","author":"Zhang","year":"2012","journal-title":"Nat Gen"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/ijc.29407\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T05:33:07Z","timestamp":1717651987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29407"}},"subtitle":["ST1926 induces apoptosis in CML cells and prolongs survival in mice"],"short-title":[],"issued":{"date-parts":[[2015,1,21]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ijc.29407","archive":["Portico"],"relation":{},"ISSN":["0020-7136"],"issn-type":[{"value":"0020-7136","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,21]]}}}