{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:47:22Z","timestamp":1791838042012,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T00:00:00Z","timestamp":1421971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Z01-CP010119"],"award-info":[{"award-number":["Z01-CP010119"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01-ES049030"],"award-info":[{"award-number":["Z01-ES049030"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Since its registration in 1994 acetochlor has become a commonly used herbicide in the US, yet no epidemiologic study has evaluated its carcinogenicity in humans. We evaluated the use of acetochlor and cancer incidence among licensed pesticide applicators in the Agricultural Health Study. In telephone interviews administered during 1999\u20132005, participants provided information on acetochlor use, use of other pesticides and additional potential confounders. We used Poisson regression to estimate relative risks (RR) and 95% confidence intervals (95% CI) for cancers that occurred from the time of interview through 2011 in Iowa and 2010 in North Carolina. Among 33,484 men, there were 4,026 applicators who used acetochlor and 3,234 incident cancers, with 304 acetochlor\u2010exposed cases. Increased risk of lung cancer was observed among acetochlor users (RR\u2009=\u20091.74; 95% CI: 1.07\u20132.84) compared to nonusers, and among individuals who reported using acetochlor\/atrazine product mixtures (RR\u2009=\u20092.33; 95% CI: 1.30\u20134.17), compared to nonusers of acetochlor. Colorectal cancer risk was significantly elevated among the highest category of acetochlor users (RR\u2009=\u20091.75; 95% CI: 1.08\u20132.83) compared to never users. Additionally, borderline significantly increased risk of melanoma (RR\u2009=\u20091.61; 95% CI: 0.98\u20132.66) and pancreatic cancer (RR\u2009=\u20092.36; 95% CI: 0.98\u20135.65) were observed among acetochlor users. The associations between acetochlor use and lung cancer, colorectal cancer, melanoma and pancreatic cancer are suggestive, however the lack of exposure\u2010response trends, small number of exposed cases and relatively short time between acetochlor use and cancer development prohibit definitive conclusions.<\/jats:p>","DOI":"10.1002\/ijc.29416","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T23:09:34Z","timestamp":1420499374000},"page":"1167-1175","source":"Crossref","is-referenced-by-count":119,"title":["Use of acetochlor and cancer incidence in the <scp>A<\/scp>gricultural <scp>H<\/scp>ealth <scp>S<\/scp>tudy"],"prefix":"10.1002","volume":"137","author":[{"given":"Catherine C.","family":"Lerro","sequence":"first","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"},{"name":"Environmental Health Sciences Department Yale University School of Public Health New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Koutros","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Andreotti","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia J.","family":"Hines","sequence":"additional","affiliation":[{"name":"Division of Surveillance Hazard Evaluations and Field Studies National Institute for Occupational Safety and Heath Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Blair","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Lubin","sequence":"additional","affiliation":[{"name":"Biostatistics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Ma","sequence":"additional","affiliation":[{"name":"Chronic Disease Epidemiology Department Yale University School of Public Health New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Environmental Health Sciences Department Yale University School of Public Health New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Beane Freeman","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,23]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Evaluation of the carcinogenic potential of acetochlor (fifth Assessment) (121601). Environmental Protection Agency Cancer Assessment Review Committee Health Effects Division Office of Pesticide Programs Washington DC 2007.1\u201366."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1413"},{"key":"e_1_2_6_4_1","unstructured":"Acetochlor (EPA\u2010HQ\u2010OPP\u20102007\u20100725\u20100002). Environmental Protection Agency Washington DC 2007."},{"key":"e_1_2_6_5_1","unstructured":"Acetochlor; Tolerance reassessment decision (EPA\u2010HQ\u2010OPP\u20102005\u20100227) vol. 71. Environmental Protection Agency Washington DC 2006.15730\u20131."},{"key":"e_1_2_6_6_1","unstructured":"Usage Report in Support of Registration for the Herbicide Acetochlor (121601). Washington DC: Environmental Protection Agency Office of Prevention Pesticides and Toxic Substances 2004."},{"key":"e_1_2_6_7_1","unstructured":"Pesticide industry sales and usage: 2006 and 2007 market estimates office of pesticide programs. Washington DC: US Environmental Protection Agency 2011."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/3434827"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/096032719601500902"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2012.06.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002775"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6417"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh040"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21758"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh290"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.96104362"},{"key":"e_1_2_6_17_1","volume-title":"International Classification of Diseases for Oncology: ICD\u2010Oed","author":"Fritz AG","year":"2000"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8124608"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws225"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901731"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.001.0001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2003.010934"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp252"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901518"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22258"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.9.841"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200101)39:1<92::AID-AJIM9>3.0.CO;2-P"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<62::AID-IJC9>3.0.CO;2-2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.10.764"},{"key":"e_1_2_6_31_1","first-page":"199","article-title":"Pancreatic cancer and serum organochlorine levels","volume":"9","author":"Hoppin JA","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24185"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1103561"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh264"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1206432"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020466"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90113-S"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90358-X"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.06.009"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2009.54"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.29416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.29416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T21:44:52Z","timestamp":1694295892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.29416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,23]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/ijc.29416"],"URL":"https:\/\/doi.org\/10.1002\/ijc.29416","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,23]]}}}