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A systematic review and meta\u2010analysis were performed to evaluate the accuracy of hrHPV testing in the management of women with AGC to detect underlying high\u2010grade intraepithelial neoplasia or worse, and adenocarcinoma <jats:italic>in situ<\/jats:italic> or worse (AIS+). Additionally, the diagnosis of extra\u2010cervical cancer was considered as an outcome in this review. A bibliographic database search (PubMed, EMBASE, CENTRAL) identified twelve eligible studies. The occurrence of cervical intraepithelial neoplasia grade two or worse including AIS+ (CIN2+\/AIS+), was 19.8% among women with AGC, and 55.7% among women with AGC and concurrent squamous lesions (atypical squamous cells of undetermined significance or worse, ASC\u2010US+). The pooled sensitivity and specificity of hrHPV\u2010testing with Hybrid Capture 2 (HC2) to detect CIN2+\/AIS+ in women with AGC was 90.0% (95% CI\u2009=\u200985.1\u201393.4%) and 75.1% (95% CI\u2009=\u200964.8\u201383.2%), respectively. Women who were hrHPV\u2010negative, demonstrated an increased risk for extra\u2010cervical malignancy (endometrium, fallopian tube, ovary). In women of 50y and older, a hrHPV\u2010negative result was linked with a 18.0% chance of extra\u2010cervical malignancy, while the chance of cervical pre\u2010cancer and cancer was 0.4 and 0.0%, respectively. In conclusion, given the high risk of underlying CIN2+\/AIS+, women with AGC should be referred directly to colposcopy. However, hrHPV test results in combination with the age, appears to improve the diagnostic process by distinguishing the risk for cervical versus non\u2010cervical lesions.<\/jats:p>","DOI":"10.1002\/ijc.29424","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T01:38:27Z","timestamp":1421113107000},"page":"303-310","source":"Crossref","is-referenced-by-count":40,"title":["<scp>H<\/scp>igh\u2010risk HPV testing in the management of atypical glandular cells: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"138","author":[{"given":"Freija","family":"Verdoodt","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology, Scientific Institute of Public Health Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Reading Hospital West Reading PA USA"},{"name":"Department of 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