{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:07:43Z","timestamp":1789164463891,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000651","name":"Leukaemia and Lymphoma Research","doi-asserted-by":"publisher","award":["08031"],"award-info":[{"award-number":["08031"]}],"id":[{"id":"10.13039\/501100000651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000651","name":"Leukaemia and Lymphoma Research","doi-asserted-by":"publisher","award":["12022"],"award-info":[{"award-number":["12022"]}],"id":[{"id":"10.13039\/501100000651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000402","name":"Kay Kendall Leukaemia Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>HLA genotyping and genome wide association studies provide strong evidence for associations between Human Leukocyte Antigen (HLA) alleles and classical Hodgkin lymphoma (cHL). Analysis of these associations is complicated by the extensive linkage disequilibrium within the major histocompatibility region and recent data suggesting that associations with EBV\u2010positive and EBV\u2010negative cHL are largely distinct. To distinguish independent and therefore potentially causal associations from associations confounded by linkage disequilibrium, we applied a variable selection regression modeling procedure to directly typed HLA class I and II genes and selected SNPs from EBV\u2010stratified patient subgroups. In final models, HLA\u2010A*01:01 and B*37:01 were associated with an increased risk of EBV\u2010positive cHL whereas DRB1*15:01 and DPB1*01:01 were associated with decreased risk. Effects were independent of a prior history of infectious mononucleosis. For EBV\u2010negative cHL the class II SNP rs6903608 remained the strongest predictor of disease risk after adjusting for the effects of common HLA alleles. Associations with \u201call cHL\u201d and differences by case EBV status reflected the subgroup analysis. In conclusion, this study extends previous findings by identifying novel HLA associations with EBV\u2010stratified subgroups of cHL, highlighting those alleles likely to be biologically relevant and strengthening evidence implicating genetic variation associated with the SNP rs6903608.<\/jats:p>","DOI":"10.1002\/ijc.29467","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T23:32:20Z","timestamp":1423006340000},"page":"1066-1075","source":"Crossref","is-referenced-by-count":35,"title":["Modeling HLA associations with EBV\u2010positive and \u2010negative <scp>H<\/scp>odgkin lymphoma suggests distinct mechanisms in disease pathogenesis"],"prefix":"10.1002","volume":"137","author":[{"given":"Paul C.D.","family":"Johnson","sequence":"first","affiliation":[{"name":"Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"McAulay","sequence":"additional","affiliation":[{"name":"MRC \u2010 University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Montgomery","sequence":"additional","affiliation":[{"name":"MRC \u2010 University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Lake","sequence":"additional","affiliation":[{"name":"MRC \u2010 University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Shield","sequence":"additional","affiliation":[{"name":"MRC \u2010 University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Gallagher","sequence":"additional","affiliation":[{"name":"MRC \u2010 University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Margaret","family":"Little","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Laboratory, Gartnavel General Hospital Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anila","family":"Shah","sequence":"additional","affiliation":[{"name":"Anthony Nolan, Royal Free Hospital Hampstead London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.E.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Anthony Nolan, Royal Free Hospital Hampstead London United Kingdom"},{"name":"Cancer Institute, University College London, Royal Free Campus London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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