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We used microsimulation modeling to estimate the cumulative number of CRC deaths prevented and colonoscopies performed between 2008 and 2038 with this family history\u2010based screening program, compared to a regular gFOBT program. In both programs, we assumed screening uptake increased from 30% (participation level in 2008 before the program was launched) to 60%. We assumed that 11% of the population had a family history, defined as having at least one first\u2010degree relative diagnosed with CRC. The programs offered screening between age 50 and 74 years, every two years for gFOBT, and every ten years for colonoscopy. Compared to opportunistic screening (2008 participation level kept constant at 30%), the gFOBT program cumulatively prevented 6,700 more CRC deaths and required 570,000 additional colonoscopies by 2038. The family history\u2010based screening program increased these numbers to 9,300 and 1,100,000, a 40% and 93% increase, respectively. If biennial gFOBT was replaced with biennial fecal immunochemical test (FIT), annual Hemoccult Sensa or five\u2010yearly sigmoidoscopy screening, both the added benefits and colonoscopies required would decrease. A biennial gFOBT screening program that identifies individuals with a family history of CRC and recommends them to undergo colonoscopy screening would prevent 40% (range in sensitivity analyses: 20\u201351%) additional deaths while requiring 93% (range: 43\u2013116%) additional colonoscopies, compared to a regular gFOBT screening program.<\/jats:p>","DOI":"10.1002\/ijc.29473","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T05:15:34Z","timestamp":1423286134000},"page":"1119-1127","source":"Crossref","is-referenced-by-count":7,"title":["The impact of stratifying by family history in colorectal cancer screening programs"],"prefix":"10.1002","volume":"137","author":[{"given":"Simon Lucas","family":"Goede","sequence":"first","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Rabeneck","sequence":"additional","affiliation":[{"name":"Prevention and Cancer Control Cancer Care Ontario Toronto Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto Canada"},{"name":"Department of Medicine University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Lansdorp\u2010Vogelaar","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann G.","family":"Zauber","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence F.","family":"Paszat","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Hoch","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Canada"},{"name":"Centre for Excellence in Economic Analysis Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean H.E.","family":"Yong","sequence":"additional","affiliation":[{"name":"Centre for Excellence in Economic Analysis Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"van Hees","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Tinmouth","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Canada"},{"name":"Department of Medicine, Division of Gastroenterology Sunnybrook Health Sciences Centre Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein","family":"van Ballegooijen","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001352"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01875.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.09.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0956"},{"key":"e_1_2_8_7_1","unstructured":"Cancer Quality Council of Ontario.Colorectal Cancer Screening Participation. 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