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For 41,514 men and women, aged 40\u201369 years, baseline (1990\u201394) dietary intakes of fatty acids were estimated using a food frequency questionnaire and plasma phospholipid (PPL) fatty acids were measured for 4,205 participants including 395 CRC cases, according to a case\u2010cohort design. Hazard ratios were computed using Cox regression adjusting for education, alcohol intake, smoking status, physical activity and total energy intake; and stratified for gender, ethnicity and family history of cancer, with age as the time scale. We assessed the heterogeneity of associations with colon and rectal cancers. PPL saturated fatty acids (SFAs) were positively associated with CRC risk, while total n\u20103 polyunsaturated fatty acids (PUFA) and long chain marine n\u20103 PUFAs showed inverse associations, significant only for 22:5 n\u20103. No significant associations were observed for dietary fatty acid intakes but positive associations with CRC of borderline significance were seen for both dietary and PPL linoleic acid. Positive associations with dietary palmitic acid (16:0), MUFAs and n\u20106 PUFAs were seen for rectal but not colon cancers. PPL 22:6 n\u20103 was inversely associated with rectal cancer. Limiting intakes of SFAs and MUFAs could be assisted by following existing guidelines to limit red and processed meats which are important sources in the Australian diet. Our observations regarding linoleic acid should be examined further.<\/jats:p>","DOI":"10.1002\/ijc.29479","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T12:25:44Z","timestamp":1423830344000},"page":"1224-1234","source":"Crossref","is-referenced-by-count":81,"title":["Dietary and biomarker estimates of fatty acids and risk of colorectal cancer"],"prefix":"10.1002","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-2197","authenticated-orcid":false,"given":"Allison M.","family":"Hodge","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne 3004 Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Farr Institute of Health Informatics Research London NW1 2DA United Kingdom"},{"name":"Department of Medical Statistics London School of Hygiene &amp; Tropical Medicine London WC1E 7HT United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Bassett","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne 3004 Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne 3004 Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne 3004 Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallas R.","family":"English","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Centre Cancer Council Victoria Melbourne 3004 Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,27]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Estimated Cancer Incidence, Mortality and Prevalence Worldwide","author":"Ferlay J","year":"2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9447-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25103"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq032"},{"key":"e_1_2_6_6_1","first-page":"590","article-title":"Meat, fish and fat intake in relation to subsite\u2010specific risk of colorectal cancer: the fukuoka colorectal cancer study. 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